Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles
	Cao, Xin 1,2; Chen, Xueli 1,2; Kang, Fei 3; Zhan, Yonghua 1,2; Cao, Xu 1,2; Wang, Jing 3; Liang, Jimin 1,2; Tian, Jie1,2,4
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-06-10
卷号	7 期号:22 页码:11775-11782
关键词	biophotonics imaging Cerenkov luminescence radioluminescence biomaterials
英文摘要	Weak intensity and poor penetration depth are two big obstacles toward clinical use of Cerenkov luminescence imaging (CLI). In this proof-of-concept study, we overcame these limitations by using lanthanides-based radioluminescent microparticles (RLMPs), called terbium doped Gd2O2S. The characterization experiment showed that the emission excited by Cerenkov luminescence can be neglected whereas the spectrum experiment demonstrated that the RLMPs can actually be excited by gamma-rays. A series of in vitro experiments demonstrated that RLMPs significantly improve the intensity and the penetration capacity of CLI, which has been extended to as deep as 15 mm. In vivo pseudotumor study further prove the huge potential of this enhancement strategy for Cerenkov luminescence imaging in living animal studies.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	STATE LIGHTING APPLICATIONS ; WHITE EMISSION ; NANOPHOSPHORS ; PROBES ; TOMOGRAPHY ; CONVERSION ; RADIATION ; PET ; FEASIBILITY ; F-18-FDG
收录类别	SCI
语种	英语
WOS记录号	WOS:000356316700010
公开日期	2015-09-22
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/7910]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cao, Xin,Chen, Xueli,Kang, Fei,et al. Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(22):11775-11782.
APA	Cao, Xin.,Chen, Xueli.,Kang, Fei.,Zhan, Yonghua.,Cao, Xu.,...&Tian, Jie.(2015).Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles.ACS APPLIED MATERIALS & INTERFACES,7(22),11775-11782.
MLA	Cao, Xin,et al."Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles".ACS APPLIED MATERIALS & INTERFACES 7.22(2015):11775-11782.