Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness

doi:10.1016/j.brs.2023.09.021

CORC > 自动化研究所 > 中国科学院自动化研究所 > 脑图谱与类脑智能实验室

	Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness
	Zhang, Haoran 8,9; Zhuang, Yutong 6; Dang, Yuanyuan 7; Ge, Qianqian 10; Yang, Yi 10; Xu, Long 10; Xia, Xiaoyu 5; Laureys, Steven 2,3,4; Yu, Shan 8,9; Zhang, Wangming 1,11
刊名	BRAIN STIMULATION
	2023-09-01
卷号	16 期号:5 页码:1522-1532
关键词	Disorders of consciousness (DoC) Deep brain stimulation (DBS) Centromedian-parafascicular complex (CM-pf) Multiunit activity (MUA) Central thalamus (CT)
ISSN号	1935-861X
DOI	10.1016/j.brs.2023.09.021
通讯作者	Yu, Shan(shan.yu@nlpr.ia.ac.cn) ; Zhang, Wangming(wzhang@vip.126.com)
英文摘要	Background: Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, the lack of understanding of its electrophysiological characteristics limits the improvement of therapeutic effect. Objective: To investigate the CM-pf electrophysiological characteristics underlying disorders of consciousness (DoC) and its recovery. Methods: We collected the CM-pf electrophysiological signals from 23 DoC patients who underwent central thalamus DBS (CT-DBS) surgery. Five typical electrophysiological features were extracted, including neuronal firing properties, multiunit activity (MUA) properties, signal stability, spike-MUA synchronization strength (syncMUA), and the background noise level. Their correlations with the consciousness level, the outcome, and the primary clinical factors of DoC were analyzed. Results: 11 out of 23 patients (0/2 chronic coma, 5/13 unresponsive wakefulness syndrome/vegetative state (UWS/VS), 6/8 minimally conscious state minus (MCS-)) exhibited an improvement in the level of consciousness after CT-DBS. In CM-pf, significantly stronger gamma band syncMUA strength and alpha band normalized MUA power were found in MCS- patients. In addition, higher firing rates, stronger high-gamma band MUA power and alpha band normalized power, and more stable theta oscillation were correlated with better outcomes. Besides, we also identified electrophysiological properties that are correlated with clinical factors, including etiologies, age, and duration of DoC. Conclusion: We provide comprehensive analyses of the electrophysiological characteristics of CM-pf in DoC patients. Our results support the 'mesocircuit' hypothesis, one proposed mechanism of DoC recovery, and reveal CM-pf electrophysiological features that are crucial for understanding the pathogenesis of DoC, predicting its recovery, and explaining the effect of clinical factors on DoC.
WOS关键词	DEEP BRAIN-STIMULATION ; ANTERIOR FOREBRAIN MESOCIRCUIT ; ALPHA-RHYTHM ; VEGETATIVE STATE ; THALAMIC-STIMULATION ; SUBTHALAMIC NUCLEUS ; AROUSAL REGULATION ; NEURONAL-ACTIVITY ; MULTIUNIT ; RECOVERY
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:001092799600001
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54400]
专题	脑图谱与类脑智能实验室
通讯作者	Yu, Shan; Zhang, Wangming
作者单位	1.Southern Med Univ, Zhujiang Hosp, Neurosurg Inst Guangdong Prov,Guangdong Prov Key L, Neurosurg Ctr,Natl Key Clin Specialty,Engn Technol, Guangzhou 510282, Peoples R China 2.Hangzhou Normal Univ, Int Consciousness Sci Inst, Hangzhou, Zhejiang, Peoples R China 3.Liege Univ Hosp, GIGA Consciousness Res Unit, Coma Sci Grp, Liege, Belgium 4.Laval Univ, CERVO Brain Res Ctr, Quebec City, PQ, Canada 5.Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Neurosurg, Beijing 100700, Peoples R China 6.Southern Med Univ, Sch Clin Med 2, Dept Neurosurg, Guangzhou, Peoples R China 7.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing 100853, Peoples R China 8.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China 9.Chinese Acad Sci, Inst Automat, Lab Brain Atlas & Brain inspired Intelligence, Beijing 100190, Peoples R China 10.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100070, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Haoran,Zhuang, Yutong,Dang, Yuanyuan,et al. Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness[J]. BRAIN STIMULATION,2023,16(5):1522-1532.
APA	Zhang, Haoran.,Zhuang, Yutong.,Dang, Yuanyuan.,Ge, Qianqian.,Yang, Yi.,...&Zhang, Wangming.(2023).Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness.BRAIN STIMULATION,16(5),1522-1532.
MLA	Zhang, Haoran,et al."Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness".BRAIN STIMULATION 16.5(2023):1522-1532.