Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys

doi:10.1002/brb3.3027

	Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
	Feng, Xiao-Li 1,2,14; Wang, Jiao-Jian 3,4; Wu, Jing 14; Ren, Xiao-Feng 5,14; Zhou, Hui 1; Li, Si-Yu 1; Zhang, Jie ; Wang, Sheng-Hai 12; Wang, Yun 6,15; Hu, Zheng-Fei 6,15
刊名	BRAIN AND BEHAVIOR
	2023-07-18
页码	10
关键词	amygdala-prefrontal connection anxious behaviors brain circuits maternal deprivation rhesus monkeys
ISSN号	2162-3279
DOI	10.1002/brb3.3027
通讯作者	Hu, Xin-Tian(xthu@mail.kiz.ac.cn) ; Jiang, Tian-Zi(jiangtz@nlpr.ia.ac.cn)
英文摘要	ObjectiveAnxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self-efficacy, self-injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavior are is closely related to changes in corresponding circuit functions in the brain. This study investigated the relationship between brain circuits and anxious behaviors in maternal-deprived rhesus monkey animal model, which mimic early adversity in human. MethodsTwenty-five rhesus monkeys (Macaca mulatta) were grouped by two different rearing conditions: 11 normal control and mother-reared (MR) monkeys and 14 maternally deprived and peer-reared (MD) monkeys. After obtaining images of the brain areas with significant differences in maternal separation and normal control macaque function, the relationship between functional junction intensity and stereotypical behaviors was determined by correlation analysis. ResultsThe correlation analysis revealed that stereotypical behaviors were negatively correlated with the coupling between the left lateral amygdala subregion and the left inferior frontal gyrus in both MD and MR macaques. ConclusionThis study suggests that early adversity-induced anxious behaviors are associated with changes in the strength of the amygdala-prefrontal connection. The normalization of the regions involved in the functional connection might reverse the behavioral abnormality. It provides a solid foundation for effective intervention in human early adversity. Significance StatementThis study suggests that early adversity-induced anxious behaviors are associated with changes in the strength of the amygdala-prefrontal connection. The higher the amygdala-prefrontal connection strength, the less stereotyped behaviors exhibited by monkeys experiencing early adversity. Thus, in the future, changing the strength of the amygdala-prefrontal connection may reverse the behavioral abnormalities of individuals who experience early adversity. This study provides a solid foundation for effective intervention in humans' early adversity.
资助项目	Joint Special Fund Project of Yunnan Provincial Science[2018FE001(-135)] ; Yunnan Province Ten Thousand Talents Program Young Top Talent
WOS关键词	MEDIAL PREFRONTAL CORTEX ; DEVELOPMENTAL EMERGENCE ; ANXIETY ; EMOTION ; FEAR ; EXPRESSION ; STRESS ; TRACTOGRAPHY ; INVOLVEMENT ; ADVERSITY
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
语种	英语
出版者	WILEY
WOS记录号	WOS:001030798900001
资助机构	Joint Special Fund Project of Yunnan Provincial Science ; Yunnan Province Ten Thousand Talents Program Young Top Talent
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53810]
专题	自动化研究所_脑网络组研究中心
通讯作者	Hu, Xin-Tian; Jiang, Tian-Zi
作者单位	1.Kunming Med Univ, Fac Basic Med Sci, Dept Physiol, Kunming, Yunnan, Peoples R China 2.Kunming Med Univ, Inst Neurosci, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Peoples R China 4.Yunnan Key Lab Primate Biomed Res, Kunming, Peoples R China 5.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Zool, Natl Res Facil Phenotyp & Genet Anal Model Anim Pr, Kunming, Yunnan, Peoples R China 7.Chinese Acad Sci, Ctr Excellence Brain Sci, Shanghai, Peoples R China 8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 10.Res Ctr Augmented Intelligence, Zhejiang Lab, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Feng, Xiao-Li,Wang, Jiao-Jian,Wu, Jing,et al. Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys[J]. BRAIN AND BEHAVIOR,2023:10.
APA	Feng, Xiao-Li.,Wang, Jiao-Jian.,Wu, Jing.,Ren, Xiao-Feng.,Zhou, Hui.,...&Jiang, Tian-Zi.(2023).Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys.BRAIN AND BEHAVIOR,10.
MLA	Feng, Xiao-Li,et al."Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys".BRAIN AND BEHAVIOR (2023):10.