The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods

doi:10.1093/cercor/bhac340

	The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods
	Zhao, Yuxin 3,4; Wang, Meng 3,4; Hu, Ke 3,4; Wang, Qi 3,4; Lou, Jing 1; Fan, Lingzhong 2,3,4; Liu, Bing 1,5
刊名	CEREBRAL CORTEX
	2022-09-07
页码	14
关键词	cortical development fMRI gene expression postnatal prenatal
ISSN号	1047-3211
DOI	10.1093/cercor/bhac340
通讯作者	Liu, Bing(bing.liu@bnu.edu.cn)
英文摘要	The human cerebral cortex conforms to specific functional hierarchies facilitating information processing and higher-order cognition. Prior studies in adults have unveiled a dominant functional hierarchy spanning from sensorimotor regions to transmodal regions, which is also present in younger cohorts. However, how the functional hierarchy develops and the underlying molecular mechanisms remain to be investigated. Here, we set out to investigate the developmental patterns of the functional hierarchy for preschool children (#scans = 141, age = 2.41-6.90 years) using a parsimonious general linear model and the underlying biological mechanisms by combining the neuroimaging developmental pattern with two separate transcriptomic datasets (i.e. Allen Human Brain Atlas and BrainSpan Atlas). Our results indicated that transmodal regions were further segregated from sensorimotor regions and that such changes were potentially driven by two gene clusters with distinct enrichment profiles, namely prenatal gene cluster and postnatal gene cluster. Additionally, we found similar developmental profiles manifested in subsequent developmental periods by conducting identical analyses on the Human Connectome Projects in Development (#scans = 638, age = 5.58-21.92 years) and Philadelphia Neurodevelopment Cohort datasets (#scans = 795, age = 8-21 years), driven by concordant two gene clusters. Together, these findings illuminate a comprehensive developmental principle of the functional hierarchy and the underpinning molecular factors, and thus may shed light on the potential pathobiology of neurodevelopmental disorders.
资助项目	National Natural Science Foun-dation of China[81771451] ; Startup Funds of Beijing Normal University
WOS关键词	DEFAULT-MODE NETWORK ; GENETIC-CONTROL ; CONNECTIVITY ; CONNECTOME ; EXPRESSION ; DYNAMICS ; PATTERNS ; DISRUPTION ; EMERGENCE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000850608200001
资助机构	National Natural Science Foun-dation of China ; Startup Funds of Beijing Normal University
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50038]
专题	自动化研究所_脑网络组研究中心
通讯作者	Liu, Bing
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr & Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Inst Brain Res, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yuxin,Wang, Meng,Hu, Ke,et al. The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods[J]. CEREBRAL CORTEX,2022:14.
APA	Zhao, Yuxin.,Wang, Meng.,Hu, Ke.,Wang, Qi.,Lou, Jing.,...&Liu, Bing.(2022).The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods.CEREBRAL CORTEX,14.
MLA	Zhao, Yuxin,et al."The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods".CEREBRAL CORTEX (2022):14.