Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment

doi:10.1016/j.carres.2022.108597

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment
	Yang, Yunhui 2; Tan, Wenqiang 1; Zhang, Jingjing 1; Guo, Zhanyong 1; Jiang, Aili 2; Li, Qing 1
刊名	CARBOHYDRATE RESEARCH
	2022-08-01
卷号	518 页码:7
关键词	Inulin Coumarin Chemical modification Antioxidant activity
ISSN号	0008-6215
DOI	10.1016/j.carres.2022.108597
通讯作者	Jiang, Aili(jal9035@163.com) ; Li, Qing(qli@yic.ac.cn)
英文摘要	In this paper, a series of target derivatives were synthesized by introducing coumarin into inulin structure using three-step chemical modification, and their structures were characterized by FTIR, H-1 NMR, and C-13 NMR. At the same time, the antioxidant activities of inulin derivatives were determined, including DPPH-radical scavenging activity, superoxide-radical scavenging activity, PTIO-radical scavenging activity and reducing ability. The test results showed that the antioxidant activities of inulin derivatives containing coumarin were significantly increased. Especially, inulin derivatives showed excellent DPPH radical-scavenging ability (IC50 0.09-0.11 mg/mL). Meanwhile, the scavenging ability of PTIO-radical was increased by more than 80%, and the IC50 values were all between 0.23 and 0.26 mg/mL. At the concentration below 1 mg/mL, the scavenging rate of all inulin derivatives could even reach 100%. This study provides a feasible way to synthesize inulin derivatives with significant activity, which may be developed into new antioxidants in medicine and cosmetics.
WOS关键词	PREBIOTIC SUPPLEMENTATION ; CHITOSANS ; HEALTH ; ASSAY
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000831011400004
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Guangdong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31608]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Jiang, Aili; Li, Qing
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China 2.Yantai Univ, Coll Life Sci, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yunhui,Tan, Wenqiang,Zhang, Jingjing,et al. Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment[J]. CARBOHYDRATE RESEARCH,2022,518:7.
APA	Yang, Yunhui,Tan, Wenqiang,Zhang, Jingjing,Guo, Zhanyong,Jiang, Aili,&Li, Qing.(2022).Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment.CARBOHYDRATE RESEARCH,518,7.
MLA	Yang, Yunhui,et al."Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment".CARBOHYDRATE RESEARCH 518(2022):7.