Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients

doi:10.1016/j.brs.2021.12.008

	Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients
	Xin, Yumeng 9,10,14; Bai, Tongjian 6,7,8; Zhang, Ting 5; Chen, Yang 4; Wang, Kai 2,3,6,7,8; Yu, Shan 1,10,11,12; Liu, Ning 3,10,14; Tian, Yanghua 3,13
刊名	BRAIN STIMULATION
	2022
卷号	15 期号:1 页码:214-225
关键词	Major depressive disorder Electroconvulsive therapy Criticality Neuronal avalanches
ISSN号	1935-861X
DOI	10.1016/j.brs.2021.12.008
通讯作者	Yu, Shan(shan.yu@nlpr.ia.ac.cn) ; Liu, Ning(liuning@ibp.ac.cn) ; Tian, Yanghua(ayfytyh@126.com)
英文摘要	Background: Electroconvulsive therapy (ECT) is widely considered as an effective and fast-acting option for treating patients with major depressive disorder (MDD). However, the neural basis underlying this powerful therapy remains uncertain. Recent studies have suggested that the healthy brain may operate near a critical state, which may reflect a balance between neuronal excitation and inhibition. Objective: In the present study, we investigated whether there are any changes regarding criticality in MDD and, if so, whether ECT can reverse them. Critical dynamics analyses were performed on restingstate functional magnetic resonance imaging (rs-fMRI) data collected from 39 MDD patients and 38 healthy controls (HCs). Results: We found that compared with HCs, MDD patients, especially those who responded positively to ECT, tended to have smaller average avalanch sizes and lower branching ratios, suggesting a sub-critical state, at both the whole-brain and functional network levels. Importantly, ECT effectively corrected such anomalies, accompanied by enhanced degree centrality and functional connectivity of high-degree nodes located in the networks including the default-mode and the frontoparietal networks. Conclusion: These results indicate that ECT can modulate large-scale brain dynamics of MDD patients to be closer to criticality. Our study sheds new light on the pathology of MDD and the network mechanism by which ECT influences treatment. (C) 2021 The Authors. Published by Elsevier Inc.
资助项目	National Key Research and Development Program of China[2017YFA0105203] ; Beijing Advanced Discipline Fund ; Strategic Priority Research Program of Chinese Academy of Science[XDB32020207] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32040200] ; Chinese Academy of Sciences[QYZDB-SSW-SMC033] ; National Natural Science Foundation of China[32071054] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[31970979] ; National Natural Science Foundation of China[82090034] ; Science Fund for Distinguished Young Scholars of Anhui Province[1808085J23] ; Beijing Academy of Artificial Intelligence
WOS关键词	NEURONAL AVALANCHES ; CORTICAL NETWORKS ; FUNCTIONAL CONNECTIVITY ; OSCILLATIONS ; ORGANIZATION ; METAANALYSIS ; PREDICTION ; REMISSION ; ECT ; MEG
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000800708100009
资助机构	National Key Research and Development Program of China ; Beijing Advanced Discipline Fund ; Strategic Priority Research Program of Chinese Academy of Science ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; Science Fund for Distinguished Young Scholars of Anhui Province ; Beijing Academy of Artificial Intelligence
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/49491]
专题	自动化研究所_脑网络组研究中心
通讯作者	Yu, Shan; Liu, Ning; Tian, Yanghua
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China 2.Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Hefei 230032, Peoples R China 3.Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei 230031, Peoples R China 4.Anhui Mental Hlth Ctr, Hefei 230022, Peoples R China 5.Anhui Med Univ, Dept Psychiat, Affiliated Hosp 2, Hefei 230601, Peoples R China 6.Collaborat Innovat Ctr Neuropsychiat Disorders &, Hefei 230032, Peoples R China 7.Anhui Prov Key Lab Cognit & Neuropsychiat Disorde, Hefei 230032, Peoples R China 8.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China 9.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 10.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xin, Yumeng,Bai, Tongjian,Zhang, Ting,et al. Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients[J]. BRAIN STIMULATION,2022,15(1):214-225.
APA	Xin, Yumeng.,Bai, Tongjian.,Zhang, Ting.,Chen, Yang.,Wang, Kai.,...&Tian, Yanghua.(2022).Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients.BRAIN STIMULATION,15(1),214-225.
MLA	Xin, Yumeng,et al."Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients".BRAIN STIMULATION 15.1(2022):214-225.