Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography

doi:10.1245/s10434-022-12028-8

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography
	Zhang, Shuaitong 6,7; Huang, Shengyu 4,5; He, Wei 3; Wei, Jingwei 7; Huo, Lei 2; Jia, Ningyang 2; Lin, Jianbo 4,5; Tang, Zhenchao 1; Yuan, Yunfei 2; Tian, Jie 1,6,7
刊名	ANNALS OF SURGICAL ONCOLOGY
	2022-07-04
页码	14
ISSN号	1068-9265
DOI	10.1245/s10434-022-12028-8
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Shen, Feng(shenfengehbh@sina.com) ; Li, Jun(lijundfgd1@163.com)
英文摘要	Background Lymph node (LN) metastasis is significantly associated with worse prognosis for patients with intrahepatic cholangiocarcinoma (ICC). Improvement in preoperative assessment on LN metastasis helps in treatment decision-making. We aimed to investigate the role of radiomics-based method in predicting LN metastasis for patients with ICC. Methods A total of 296 patients with ICC who underwent curative-intent hepatectomy and lymphadenectomy at two centers in China were analyzed. Radiomic features, including histogram- and wavelet-based features, shape and size features, and texture features were extracted from four-phase computerized tomography (CT) images. The clinical and conventional radiological variables which were independently associated with LN metastasis were also identified. A combined nomogram predicting LN metastasis was developed, and its performance was determined by discrimination, calibration, and stratification of long-term prognosis. The results were validated by the internal and external validation cohorts. Results Twenty-four radiomic features were selected into the nomogram. The established nomogram demonstrated good discrimination and calibration, with areas under the curve (AUCs) of 0.98 [95% confidence interval (CI) 0.96-0.99], 0.93 (0.88-0.98), and 0.89 (0.81-0.96) in the training and two validation cohorts, respectively. The 5-year overall survival (OS) and recurrence-free survival (RFS) rates of patients with high risk of LN metastasis as grouped by nomogram were poorer than those of patients with low risk in the training cohort (OS 28.8% versus 53.9%, p < 0.001; RFS 26.3% versus 44.2%, p = 0.001). Similar results were observed in the two validation cohorts. Conclusions Radiomics-based method provided accurate prediction of LN metastasis and prognostic assessment for ICC patients, and might aid the preoperative surgical decision.
资助项目	National Natural Science Foundation of China[81772531] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[82102140] ; National Natural Science Foundation of China[81930053] ; Program of Shanghai Academic/Technology Research Leader[19XD1425000] ; Program of Shanghai for Key Clinical Disciplines Construction[shslczdzk02402] ; Program of Shanghai for Medical Guide[18411968900] ; Program of Shanghai for Clinical Skill Training and Clinical Practice Innovations[SHDC2020CR4027] ; Program of Shanghai for Clinical Skill Training and Clinical Practice Innovations[SHDC2020CR5007] ; Program of Shanghai for Clinical Skill Training and Clinical Practice Innovations[SHDC12019110]
WOS关键词	LYMPHADENECTOMY ; MANAGEMENT ; NOMOGRAM
WOS研究方向	Oncology ; Surgery
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000820535000005
资助机构	National Natural Science Foundation of China ; Program of Shanghai Academic/Technology Research Leader ; Program of Shanghai for Key Clinical Disciplines Construction ; Program of Shanghai for Medical Guide ; Program of Shanghai for Clinical Skill Training and Clinical Practice Innovations
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/49185]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Shen, Feng; Li, Jun
作者单位	1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Shanxi, Peoples R China 2.Naval Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Radiotherapy, Shanghai, Peoples R China 3.Sun Yat Sen Univ, Dept Hepatobiliary Oncol, Canc Ctr, Guangzhou, Peoples R China 4.Naval Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 4, Shanghai, Peoples R China 5.Tongji Univ, Dept Hepatobiliary & Pancreat Surg, Peoples Hosp 10, Shanghai, Peoples R China 6.Beihang Univ, Sch Engn Med, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shuaitong,Huang, Shengyu,He, Wei,et al. Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography[J]. ANNALS OF SURGICAL ONCOLOGY,2022:14.
APA	Zhang, Shuaitong.,Huang, Shengyu.,He, Wei.,Wei, Jingwei.,Huo, Lei.,...&Li, Jun.(2022).Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography.ANNALS OF SURGICAL ONCOLOGY,14.
MLA	Zhang, Shuaitong,et al."Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography".ANNALS OF SURGICAL ONCOLOGY (2022):14.