p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing

doi:10.1523/JNEUROSCI.1287-21.2021

	p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing
	Li, Jin 5,6; Cao, Dan 5,6; Dimakopoulos, Vasileios 4; Shi, Weiyang 3,5,6; Yu, Shan 3,5,6,8; Fan, Lingzhong 3,5,6,8; Stieglitz, Lennart 4; Imbach, Lukas 7; Sarnthein, Johannes 1,4; Jiang, Tianzi 2,3,5,6,8
刊名	JOURNAL OF NEUROSCIENCE
	2022-01-19
卷号	42 期号:3 页码:443-453
关键词	hippocampus intracranial EEG longitudinal axis working memory
ISSN号	0270-6474
DOI	10.1523/JNEUROSCI.1287-21.2021
通讯作者	Sarnthein, Johannes(johannes.samthein@usz.ch) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要	The hippocampus is a locus of working memory (WM) with anterior and posterior subregions that differ in their transcriptional and external connectivity patterns. However, the involvement and functional connections between these subregions in WM processing are poorly understood. To address these issues, we recorded intracranial EEG from the anterior and the posterior hippocampi in humans (seven females and seven males) who maintained a set of letters in their WM. We found that WM maintenance was accompanied by elevated low-frequency activity in both the anterior and posterior hippocampus and by increased theta/alpha band (3-12 Hz) phase synchronization between anterior and posterior subregions. Cross-frequency and Granger prediction analyses consistently showed that the correct WM trials were associated with theta/alpha band-coordinated unidirectional influence from the posterior to the anterior hippocampus. In contrast, WM errors were associated with bidirectional interactions between the anterior and posterior hippocampus. These findings imply that theta/alpha band synchrony within the hippocampus may support successful WM via a posterior to anterior influence. A combination of intracranial recording and a fine-grained atlas may be of value in understanding the neural mechanisms of WM processing.
资助项目	National Key Research and Development Program of China[2017YFA0105203] ; Chinese Academy of Sciences Science and Technology Service Network Initiative[KFJ-STSZDTP-078] ; National Natural Science Foundation of China[31300934] ; National Natural Science Foundation of China[31620103905] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB2004] ; CAS Key Laboratory of Behavioral Science ; Swiss National Science Foundation[SNSF 176222] ; Institute of Psychology
WOS关键词	PERSISTENTLY ACTIVE NEURONS ; THETA-OSCILLATIONS ; VENTRAL HIPPOCAMPUS ; LONG-AXIS ; ORGANIZATION ; DORSAL ; DISSOCIATION ; TOOLBOX ; GAMMA ; RAT
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000746045100002
资助机构	National Key Research and Development Program of China ; Chinese Academy of Sciences Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; CAS Key Laboratory of Behavioral Science ; Swiss National Science Foundation ; Institute of Psychology
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/47253]
专题	中国科学院自动化研究所
通讯作者	Sarnthein, Johannes; Jiang, Tianzi
作者单位	1.Swiss Fed Inst Technol, Zurich Neurosci Ctr, CH-8057 Zurich, Switzerland 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 4.Univ Zurich, Univ Hosp Zurich, Dept Neurosurg, CH-8091 Zurich, Switzerland 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 7.Swiss Epilepsy Ctr, CH-8008 Zurich, Switzerland 8.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Jin,Cao, Dan,Dimakopoulos, Vasileios,et al. p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing[J]. JOURNAL OF NEUROSCIENCE,2022,42(3):443-453.
APA	Li, Jin.,Cao, Dan.,Dimakopoulos, Vasileios.,Shi, Weiyang.,Yu, Shan.,...&Jiang, Tianzi.(2022).p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing.JOURNAL OF NEUROSCIENCE,42(3),443-453.
MLA	Li, Jin,et al."p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing".JOURNAL OF NEUROSCIENCE 42.3(2022):443-453.