DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing

doi:10.1093/cercor/bhab117

	DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing
	Cheng, Weiqiu 1,2; Luo, Na 3,4; Zhang, Yuyanan 1,2; Zhang, Xiao 1,2; Tan, Haoyang 5,6; Zhang, Dai 1,2,7,8; Sui, Jing 4,9; Yue, Weihua 1,2,8; Yan, Hao 1,2
刊名	CEREBRAL CORTEX
	2021-10-01
卷号	31 期号:10 页码:4709-4718
关键词	cognition DNA methylation spontaneous brain activity superior temporal gyrus urbanicity
ISSN号	1047-3211
DOI	10.1093/cercor/bhab117
通讯作者	Sui, Jing(kittysj@gmail.com) ; Yue, Weihua(dryue@bjmu.edu.cn) ; Yan, Hao(hao_y@bjmu.edu.cn)
英文摘要	Urbanicity has been suggested to affect cognition, but the underlying mechanism remains unknown. We examined whether epigenetic modification (DNA methylation, DNAm), and brain white matter fiber integrity (fractional anisotropy, FA) or local spontaneous brain function activity (regional homogeneity, ReHo) play roles in the association between childhood urbanicity and cognition based on 497 healthy Chinese adults. We found significant correlation between childhood urbanicity and better cognitive performance. Multiset canonical correlation analysis (mCCA) identified an intercorrelated DNAm-FA-ReHo triplet, which showed significant pairwise correlations (DNAm-FA: Bonferroni-adjusted P, P-bon=4.99E-03, rho=0.216; DNAm-ReHo: P-bon=4.08E-03, rho=0.239; ReHo-FA: P-bon=1.68E-06, rho=0.328). Causal mediation analysis revealed that 1) ReHo mediated 10.86% childhood urbanicity effects on the speed of processing and 2) childhood urbanicity alters ReHo through DNA methylation in the cadherin and Wnt signaling pathways (mediated effect: 48.55%). The mediation effect of increased ReHo in the superior temporal gyrus underlying urbanicity impact on a better speed of processing was further validated in an independent cohort. Our work suggests a mediation role for ReHo, particularly increased brain activity in the superior temporal gyrus, in the urbanicity-associated speed of processing.
资助项目	National Key R&D Program of China[2016YFC1307000] ; National Key R&D Program of China[2016YFC1307201] ; Natural Science Foundation of China[81771443] ; Natural Science Foundation of China[81825009] ; Natural Science Foundation of China[31771186] ; Natural Science Foundation of China[81361120395] ; Natural Science Foundation of China[82022035] ; Natural Science Foundation of China[61773380] ; Natural Science Foundation of China[82001450] ; Peking University Clinical Scientist Program - the Fundamental Research Funds for the Central Universities[BMU2019LCKXJ012] ; Chinese Institute for Brain Research at Beijing[2020-NKX-XM-12] ; Postdoctoral Science Foundation[BX20200364]
WOS关键词	CONSENSUS COGNITIVE BATTERY ; URBANIZATION ; PERFORMANCE ; CEREBELLUM ; ATTENTION ; PATTERNS ; CHILDREN ; HISTORY ; MEMORY ; RISK
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000695807700021
资助机构	National Key R&D Program of China ; Natural Science Foundation of China ; Peking University Clinical Scientist Program - the Fundamental Research Funds for the Central Universities ; Chinese Institute for Brain Research at Beijing ; Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/46013]
专题	自动化研究所_脑网络组研究中心
通讯作者	Sui, Jing; Yue, Weihua; Yan, Hao
作者单位	1.Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China 2.Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Lieber Inst Brain Dev, Baltimore, MD 21205 USA 6.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA 7.Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing 100871, Peoples R China 8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China 9.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Weiqiu,Luo, Na,Zhang, Yuyanan,et al. DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing[J]. CEREBRAL CORTEX,2021,31(10):4709-4718.
APA	Cheng, Weiqiu.,Luo, Na.,Zhang, Yuyanan.,Zhang, Xiao.,Tan, Haoyang.,...&Yan, Hao.(2021).DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.CEREBRAL CORTEX,31(10),4709-4718.
MLA	Cheng, Weiqiu,et al."DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing".CEREBRAL CORTEX 31.10(2021):4709-4718.