Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus

	Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus
	Liu Zhenjia 4; Yang Yanjuan 1; Jiang Lei 4; Xu Yingchun 2; Wang Aixia 3; Du Guanhua 5; Gao Jinming 4
刊名	ACTA PHARMACOLOGICA SINICA
	2011
卷号	32 期号:8 页码:1038
关键词	CHEMOKINE RECEPTORS LIGAND-BINDING ANAPHYLATOXIN RECOGNITION RESIDUES C5L2 Staphylococcus aureus chemotaxis inhibitory protein tyrosine sulfation post-translational modification chemotactic receptor C5aR
ISSN号	1671-4083
英文摘要	Aim: Staphylococcus aureus evades host defense through releasing several virulence proteins, such as chemotaxis inhibitory protein of staphylococcus aureus (CHIPS). It has been shown that extracellular N terminus of C5a receptor (C5aR) forms the binding domain for CHIPS, and tyrosine sulfation is emerging as a key factor in determining protein-protein interaction. The aim of this study was to evaluate the role of tyrosine sulfation of N-terminal of C5aR in its binding with CHIPS.
资助项目	[National Natural Science Foundation of China] ; [Beijing Natural Sciences Foundation] ; [Education Ministry of China New Century Excellent Talent] ; [Janssen Research Council China]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292742]
专题	中国科学院上海药物研究所
作者单位	1.Ningxia Med University, Dept Resp Dis, Affiliated Hosp, Yinchuan 750004, Peoples R China 2.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Med Microbiol, Beijing 100730, Peoples R China 3.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Infect Dis, Beijing 100730, Peoples R China 4.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Resp Dis, Beijing 100730, Peoples R China 5.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Liu Zhenjia,Yang Yanjuan,Jiang Lei,et al. Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus[J]. ACTA PHARMACOLOGICA SINICA,2011,32(8):1038.
APA	Liu Zhenjia.,Yang Yanjuan.,Jiang Lei.,Xu Yingchun.,Wang Aixia.,...&Gao Jinming.(2011).Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus.ACTA PHARMACOLOGICA SINICA,32(8),1038.
MLA	Liu Zhenjia,et al."Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus".ACTA PHARMACOLOGICA SINICA 32.8(2011):1038.