Identification of genes with altered roles in transcription network in Alzheimer's disease | |
Hua, Jiaojiao2,3; Yu,Shan1,2,4 | |
2021 | |
会议日期 | 2021.05.21-2021.05.23 |
会议地点 | 中国西安 |
英文摘要 | Differentially expressed genes (DEGs) are commonly used to study the pathological mechanism of various brain diseases. However, these analyses are not sufficient to identify genes that alter their roles in the transcription networks but without significant changes in the expression level. By analyzing an RNA microarray dataset (GSE36980) from Gene Expression Omnibus (GEO), we find that many genes exhibit changes in how their transcriptions are correlated with that of the entire genome in the samples of Alzheimer’s disease (AD) patients, when compared with the normal controls. We name such genes as role-alteration genes (RAGs). Only a minority of RAGs also show significant changes in the expression level. Within the pools of RAGs, we further identified clustered biological functions through gene ontology (GO) analyses, suggesting the functional significance of these RAGs. Our work provides novel insights into the genes that may be involved in AD but cannot be captured by common DEG analyses, suggesting more profound changes in the transcription network during diseases than previously appreciated. |
内容类型 | 会议论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/44806] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Yu,Shan |
作者单位 | 1.School of Future Technology, University of Chinese Academy of Sciences 2.Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences 3.School of Artificial Intelligence, University of Chinese Academy of Sciences 4.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Hua, Jiaojiao,Yu,Shan. Identification of genes with altered roles in transcription network in Alzheimer's disease[C]. 见:. 中国西安. 2021.05.21-2021.05.23. |
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