Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance

doi:10.1038/s41598-020-61647-2

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	Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance
	Zhang, Qian 2,3; Zeng, Yi 1,2,3,4; Yang, Taoyi 2
刊名	SCIENTIFIC REPORTS
	2020-03-13
卷号	10 期号:1 页码:9
ISSN号	2045-2322
DOI	10.1038/s41598-020-61647-2
通讯作者	Zhang, Qian(q.zhang@ia.ac.cn) ; Zeng, Yi(yi.zeng@ia.ac.cn)
英文摘要	Interneurons play crucial roles in neocortex associated with high-level cognitive functions; however, the specific division of labor is still under investigation. Interneurons are exceptionally diverse in their morphological appearance and functional properties. In this study, we modify a prefrontal multicolumn circuit in which five subtypes of inhibitory interneurons play distinct roles in the maintenance of transient information. These interneurons are classified according to the extending range of axonal projections. Our work simplifies the division of labor between different types of interneurons for the maintenance of information and the principle of functional redundancy of the brain from the perspective of computational modeling. This model presents a framework to understand the cooperation between different interneurons in a recurrent cortical circuit.
资助项目	Key Research Program of Frontier Sciences, CAS[ZDBS-LY-JSC013] ; Brain-inspired Cognition of Consciousness and Anesthesia[Y8D1051LE1] ; National Natural Science Foundation of China[81501594] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32070100] ; Beijing Municipality of Science and Technology[Z181100001518006] ; Major Research Program of Shandong Province[2018CXGC1503]
WOS关键词	INHIBITORY NEURONS ; PYRAMIDAL NEURON ; ORGANIZATION ; MODEL ; SUBNETWORKS ; CONNECTIONS ; COLUMNAR ; RELEASE ; AXON ; RAT
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000563437800007
资助机构	Key Research Program of Frontier Sciences, CAS ; Brain-inspired Cognition of Consciousness and Anesthesia ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Beijing Municipality of Science and Technology ; Major Research Program of Shandong Province
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/40542]
专题	类脑智能研究中心_类脑认知计算
通讯作者	Zhang, Qian; Zeng, Yi
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qian,Zeng, Yi,Yang, Taoyi. Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance[J]. SCIENTIFIC REPORTS,2020,10(1):9.
APA	Zhang, Qian,Zeng, Yi,&Yang, Taoyi.(2020).Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance.SCIENTIFIC REPORTS,10(1),9.
MLA	Zhang, Qian,et al."Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance".SCIENTIFIC REPORTS 10.1(2020):9.