NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy | |
Zhi, Dongmei1,7,8; Wu, Wenyue2,3; Xiao, Bo2; Qi, Shile4; Jiang, Rongtao1,7,8; Yang, Xingdong6; Yang, Jian9; Xiao, Wenbiao2; Liu, Chaorong2; Long, Hongyu2 | |
刊名 | FRONTIERS IN NEUROSCIENCE |
2020-07-14 | |
卷号 | 14期号:727页码:10 |
关键词 | temporal lobe epilepsy multimodal fusion functional connectivity fractional anisotropy gray matter volume |
DOI | 10.3389/fnins.2020.00727 |
英文摘要 | DNA hypermethylation has been widely observed in temporal lobe epilepsy (TLE), in which NR4A1 knockdown has been reported to be able to alleviate seizure severity in mouse model, while the underlying methylation-imaging pathway modulated by aberrant methylation levels of NR4A1 remains to be clarified in patients with TLE. Here, using multi-site canonical correlation analysis with reference, methylation levels of NR4A1 in blood were used as priori to guide fusion of three MRI features: functional connectivity (FC), fractional anisotropy (FA), and gray matter volume (GMV) for 56 TLE patients and 65 healthy controls. Post-hoc correlations were further evaluated between the identified NR4A1-associated brain components and disease onset. Results suggested that higher NR4A1 methylation levels in TLE were related with impaired temporal-cerebellar and occipital-cerebellar FC strength, lower FA in cingulum (hippocampus), and reduced GMV in putamen, temporal pole, and cerebellum. Moreover, findings were also replicated well in both patient subsets with either right TLE or left TLE only. Particularly, right TLE patients showed poorer cognitive abilities and more severe brain impairment than left TLE patients, especially more reduced GMV in thalamus. In summary, this work revealed a potential imaging-methylation pathway modulated by higher NR4A1 methylation in TLE via data mining, which may impact the above-mentioned multimodal brain circuits and was also associated with earlier disease onset and more cognitive deficits. |
资助项目 | National Natural Science Foundation[61773380] ; National Natural Science Foundation[81671300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32040100] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; Key Research Project of the Chinese Ministry of Science and Technology[2016YFC0904400] ; Clinical Research Foundation of Xiangya Hospital[2016L08] ; National Institute of Health[1R01MH117107] ; National Institute of Health[P20GM103472] |
WOS关键词 | WHITE-MATTER ABNORMALITIES ; VOXEL-BASED MORPHOMETRY ; EPIGENETIC MECHANISMS ; CEREBELLAR ATROPHY ; SEIZURE ONSET ; THALAMUS ; EXPRESSION ; SCLEROSIS ; DURATION ; BRAIN |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000556758900001 |
资助机构 | National Natural Science Foundation ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Key Research Project of the Chinese Ministry of Science and Technology ; Clinical Research Foundation of Xiangya Hospital ; National Institute of Health |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/40356] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Long, Lili; Sui, Jing |
作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Peoples R China 3.Nanchang Univ, Affiliated Hosp 2, Dept Neurol, Nanchang, Jiangxi, Peoples R China 4.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA 5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing, Peoples R China 6.Beijing Haidian Hosp, Dept Neurol, Beijing, Peoples R China 7.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 9.Beijing Inst Technol, Sch Opt & Elect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhi, Dongmei,Wu, Wenyue,Xiao, Bo,et al. NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy[J]. FRONTIERS IN NEUROSCIENCE,2020,14(727):10. |
APA | Zhi, Dongmei.,Wu, Wenyue.,Xiao, Bo.,Qi, Shile.,Jiang, Rongtao.,...&Sui, Jing.(2020).NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy.FRONTIERS IN NEUROSCIENCE,14(727),10. |
MLA | Zhi, Dongmei,et al."NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy".FRONTIERS IN NEUROSCIENCE 14.727(2020):10. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论