Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo | |
Zhang, Xianghan3; Zhao, Sumei3; Gao, Zhiqing3; Zhou, Jialin3; Xia, Yuqiong3; Tian, Jie2,3; Shi, Changhong1; Wang, Zhongliang3 | |
刊名 | NANO RESEARCH |
2021-02-27 | |
页码 | 9 |
关键词 | cancer phototheranostics NIR cyanine liposome mitochondria-targeted phototherapy |
ISSN号 | 1998-0124 |
DOI | 10.1007/s12274-020-3246-2 |
通讯作者 | Tian, Jie(tian@ieee.org) ; Shi, Changhong(changhong@fmmu.edu.cn) ; Wang, Zhongliang(wangzl@xidian.edu.cn) |
英文摘要 | Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PIT) is a localized noninvasive approach in treating cancer. Mitochondria-targeted near-infrared (NIR) cyanines are excellent therapeutic photosensitizers of cancer. However, most mitochondria-targeted cyanines exist in the form of hydrophobic structures, which in vivo may cause cyanine aggregation during blood circulation, resulting in poor biocompatibility and limited therapeutic efficacy. Therefore, we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers (CyBI7-LPs), which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting. Moreover, CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species (ROS) could rapidly escape from the liposomal bilayer, affording enhanced PTT/PDT efficacy. Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyB17-LPB. The CyBI7-LPB probe produced a tumor-to-background ratio (TBR) of approximately 6.4 at 24 HPI. Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects. This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy. |
资助项目 | National Key Research and Development Program of China[2017YFC1309100] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[91959124] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[21804104] ; Natural Science Foundation of Shaanxi Province of China[2020PT-020] ; Key Research and Development Program of Shaanxi Province[2019NY-085] ; Natural Science Basic Research Program of Shaanxi Province of China[2019JQ-139] ; Natural Science Basic Research Program of Shaanxi Province of China[2019JQ-662] ; Natural Science Basic Research Program of Shaanxi Province of China[2018JM2041] ; Fundamental Research Funds for the Central Universities[JB191211] ; Fundamental Research Funds for the Central Universities[JB191207] ; Fundamental Research Funds for the Central Universities[JB191208] ; Open Project Program of the State Key Laboratory of Cancer Biology (Fourth Military Medical University)[CBSKL2019ZDKF06] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | TSINGHUA UNIV PRESS |
WOS记录号 | WOS:000622225700001 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province of China ; Key Research and Development Program of Shaanxi Province ; Natural Science Basic Research Program of Shaanxi Province of China ; Fundamental Research Funds for the Central Universities ; Open Project Program of the State Key Laboratory of Cancer Biology (Fourth Military Medical University) |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/43324] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
通讯作者 | Tian, Jie; Shi, Changhong; Wang, Zhongliang |
作者单位 | 1.Fourth Mil Med Univ, Lab Anim Ctr, Xian 710032, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuroimaging, Xian 710026, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Xianghan,Zhao, Sumei,Gao, Zhiqing,et al. Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo[J]. NANO RESEARCH,2021:9. |
APA | Zhang, Xianghan.,Zhao, Sumei.,Gao, Zhiqing.,Zhou, Jialin.,Xia, Yuqiong.,...&Wang, Zhongliang.(2021).Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo.NANO RESEARCH,9. |
MLA | Zhang, Xianghan,et al."Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo".NANO RESEARCH (2021):9. |
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