Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging | |
Li, Yiming6; Liang, Yuchao5; Sun, Zhiyan6; Xu, Kaibin1; Fan, Xing6; Li, Shaowu7; Zhang, Zhong5; Jiang, Tao2,3,4; Liu, Xing6; Wang, Yinyan5 | |
刊名 | NEURORADIOLOGY |
2019-11-01 | |
卷号 | 61期号:11页码:1229-1237 |
关键词 | Glioblastoma Radiogenomics Phosphatase and tensin homolog (PTEN) Machine learning |
ISSN号 | 0028-3940 |
DOI | 10.1007/s00234-019-02244-7 |
通讯作者 | Wang, Yinyan(tiantanyinyan@126.com) |
英文摘要 | Purpose PTEN mutation status is a pivotal biomarker for glioblastoma. This study aimed to establish a radiomic signature to predict PTEN mutation status in patients with glioblastoma, and to investigate the genetic background behind this radiomic signature. Methods In this study, a total of 862 radiomic features were extracted from each patient. The training (n = 69) and validation (n = 40) sets were retrospectively collected from the Cancer Genome Atlas and the Chinese Glioma Genome Atlas, respectively. The minimum redundancy maximum relevance (mRMR) algorithm was used to select the best predictive features of PTEN status. A machine learning model was then built with the selected features using a support vector machine classifier. The predictive performance of each selected feature and the complete model were evaluated via the area under the curve from receiver operating characteristic analysis in both the training and validation sets. The genetic background underlying the radiomic signature was determined using radiogenomic analysis. Results Six features were selected using the mRMR algorithm, including two features derived from contrast-enhanced images and four features derived from T2-weighted images. The predictive performance of the machine learning model for the training and validation sets were 0.925 and 0.787, respectively, which were better than the individual features. Radiogenomics analysis revealed that the PTEN-associated biological processes could be described using the radiomic signature. Conclusion These results show that radiomic features derived from preoperative MRI can predict PTEN mutation status in glioblastoma patients, thus providing a novel noninvasive imaging biomarker. |
资助项目 | National Natural Science Foundation of China[81601452] ; Beijing Natural Science Foundation[7174295] ; National Key Research and Development Plan[2016YFC0902500] ; National Key Research and Development Program of China[2018YFC0115604] |
WOS关键词 | MRI FEATURES ; TUMOR ; CLASSIFICATION ; GLIOMAS ; GENE ; EXPRESSION ; BIOMARKERS ; COMPLEXES ; PATHWAYS ; TEXTURE |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
出版者 | SPRINGER |
WOS记录号 | WOS:000503025800003 |
资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Key Research and Development Plan ; National Key Research and Development Program of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/29425] |
专题 | 综合信息系统研究中心_脑机融合与认知评估 |
通讯作者 | Wang, Yinyan |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 2.Chinese Glioma Genome Atlas Network CGGA, Beijing, Peoples R China 3.Asian Glioma Genome Atlas Network AGGA, Beijing, Peoples R China 4.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China 5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 6 Tiantanxili, Beijing 100050, Peoples R China 6.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China 7.Capital Med Univ, Beijing Neurosurg Inst, Neurol Imaging Ctr, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Yiming,Liang, Yuchao,Sun, Zhiyan,et al. Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging[J]. NEURORADIOLOGY,2019,61(11):1229-1237. |
APA | Li, Yiming.,Liang, Yuchao.,Sun, Zhiyan.,Xu, Kaibin.,Fan, Xing.,...&Wang, Yinyan.(2019).Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging.NEURORADIOLOGY,61(11),1229-1237. |
MLA | Li, Yiming,et al."Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging".NEURORADIOLOGY 61.11(2019):1229-1237. |
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