Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer

doi:10.1126/sciadv.aax6040

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer
	You, Huijuan 3,5; Shang, Wenting 5; Min, Xiangde 3; Weinreb, Jeffrey 4; Li, Qiubai 1; Leapman, Michael 2; Wang, Liang 3; Tian, Jie 5,6
刊名	SCIENCE ADVANCES
	2020-02-01
卷号	6 期号:6 页码:14
ISSN号	2375-2548
DOI	10.1126/sciadv.aax6040
通讯作者	Shang, Wenting(wenting.shang@ia.ac.cn) ; Wang, Liang(wang6@tjh.tjmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要	Nerve density is associated with prostate cancer (PCa) aggressiveness and prognosis. Thus far, no visualization methods have been developed to assess nerve density of PCa in vivo. We compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs), which achieved the nerve density visualization of PCa with high sensitivity and high specificity, and facilitated assessment of nerve density and aggressiveness of PCa using magnetic resonance imaging and magnetic particle imaging. Moreover, PSN NPs facilitated targeted therapy for PCa. PSN NPs increased the survival rate of mice with orthotopic PCa to 83.3% and decreased nerve densities and proliferation indexes by more than twofold compared with the control groups. The present study, thus, developed a technology to visualize the nerve density of PCa and facilitate targeted neural drug delivery to tumors to efficiently inhibit PCa progression. Our study provides a potential basis for clinical imaging and therapeutic interventions targeting nerves in PCa.
资助项目	National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200]
WOS关键词	ESTRO-SIOG GUIDELINES ; SUPERPARAMAGNETIC NANOPARTICLES ; RAT ; SENSITIVITY ; RESOLUTION ; PROBES
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000512902300010
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/28596]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Shang, Wenting; Wang, Liang; Tian, Jie
作者单位	1.UT Southwestern Med Ctr, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA 2.Yale Univ, Sch Med, Dept Urol, New Haven, CT 06520 USA 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Radiol, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 4.Yale Univ, Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA 5.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	You, Huijuan,Shang, Wenting,Min, Xiangde,et al. Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer[J]. SCIENCE ADVANCES,2020,6(6):14.
APA	You, Huijuan.,Shang, Wenting.,Min, Xiangde.,Weinreb, Jeffrey.,Li, Qiubai.,...&Tian, Jie.(2020).Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer.SCIENCE ADVANCES,6(6),14.
MLA	You, Huijuan,et al."Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer".SCIENCE ADVANCES 6.6(2020):14.