A single-cell transcriptomic landscape of primate arterial aging

doi:10.1038/s41467-020-15997-0

CORC > 自动化研究所 > 中国科学院自动化研究所 > 模式识别国家重点实验室 > 生物识别与安全技术研究中心

	A single-cell transcriptomic landscape of primate arterial aging
	Zhang, Weiqi 9,10,11,12,13,14; Zhang, Shu 7,8; Yan, Pengze 1,12; Ren, Jie 6,7; Song, Moshi 1,9,12; Li, Jingyi 1,12,13; Lei, Jinghui 10,11; Pan, Huize 12,13; Wang, Si 1,9,12; Ma, Xibo 4,5,12
刊名	NATURE COMMUNICATIONS
	2020-05-05
卷号	11 期号:1 页码:13
ISSN号	2041-1723
DOI	10.1038/s41467-020-15997-0
通讯作者	Liu, Guang-Hui(ghliu@ioz.ac.cn) ; Tang, Fuchou(tangfuchou@pku.edu.cn) ; Qu, Jing(qujing@ioz.ac.cn)
英文摘要	Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we report a single-cell transcriptomic survey of aortas and coronary arteries in young and old cynomolgus monkeys. Our data define the molecular signatures of specialized arteries and identify eight markers discriminating aortic and coronary vasculatures. Gene network analyses characterize transcriptional landmarks that regulate vascular senility and position FOXO3A, a longevity-associated transcription factor, as a master regulator gene that is downregulated in six subtypes of monkey vascular cells during aging. Targeted inactivation of FOXO3A in human vascular endothelial cells recapitulates the major phenotypic defects observed in aged monkey arteries, verifying FOXO3A loss as a key driver for arterial endothelial aging. Our study provides a critical resource for understanding the principles underlying primate arterial aging and contributes important clues to future treatment of age-associated vascular disorders. Arterial degeneration, closely associated with cardiovascular diseases, is driven by aging-related vascular cell-specific transcriptomics changes. This study provides a single-cell transcriptomic atlas for senile aortic and coronary arteries and underscores FOXO3A-based the transcriptional network in vasoprotection during aging.
资助项目	National Key Research and Development Program of China[2017YFA0103304] ; National Key Research and Development Program of China[2017YFA0102802] ; National Key Research and Development Program of China[2018YFA0107203] ; National Key Research and Development Program of China[2018YFC2000400] ; National Key Research and Development Program of China[2018YFC2000100] ; National Key Research and Development Program of China[2016YFA0100902] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16010100] ; National Natural Science Foundation of China[81921006] ; National Natural Science Foundation of China[81625009] ; National Natural Science Foundation of China[91749202] ; National Natural Science Foundation of China[81861168034] ; National Natural Science Foundation of China[31671429] ; National Natural Science Foundation of China[91949209] ; National Natural Science Foundation of China[81671377] ; National Natural Science Foundation of China[91749123] ; National Natural Science Foundation of China[81822018] ; National Natural Science Foundation of China[81870228] ; National Natural Science Foundation of China[81922027] ; National Natural Science Foundation of China[81701388] ; National Natural Science Foundation of China[81801399] ; National Natural Science Foundation of China[81801370] ; Program of Beijing Municipal Science and Technology Commission[Z191100001519005] ; Beijing Natural Science Foundation[Z190019] ; Beijing Municipal Commission of Health and Family Planning[PXM2018_026283_000002] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-221] ; Advanced Innovation Center for Human Brain Protection[3500-1192012] ; K.C. Wong Education Foundation[GJTD-2019-06] ; K.C. Wong Education Foundation[GJTD-2019-08] ; Youth Innovation Promotion Association of CAS ; Young Elite Scientists Sponsorship Program by CAST[2017QNRC001] ; China Postdoctoral Science Foundation[2018M640154] ; State Key Laboratory of Stem Cell and Reproductive Biology ; State Key Laboratory of Membrane Biology ; Beijing Advanced Innovation Center for Genomics (ICG) at Peking University
WOS关键词	ATHEROSCLEROSIS ; EXPRESSION ; ATLAS ; QUANTIFICATION ; RECONSTRUCTION ; INTEGRATION ; MECHANISMS ; REGULATORS ; SIGNATURES ; INFERENCE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000532362000001
资助机构	National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Program of Beijing Municipal Science and Technology Commission ; Beijing Natural Science Foundation ; Beijing Municipal Commission of Health and Family Planning ; Key Research Program of the Chinese Academy of Sciences ; Advanced Innovation Center for Human Brain Protection ; K.C. Wong Education Foundation ; Youth Innovation Promotion Association of CAS ; Young Elite Scientists Sponsorship Program by CAST ; China Postdoctoral Science Foundation ; State Key Laboratory of Stem Cell and Reproductive Biology ; State Key Laboratory of Membrane Biology ; Beijing Advanced Innovation Center for Genomics (ICG) at Peking University
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/39480]
专题	自动化研究所_模式识别国家重点实验室_生物识别与安全技术研究中心
通讯作者	Liu, Guang-Hui; Tang, Fuchou; Qu, Jing
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China 2.Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Automat, NLPR, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, CBSR, Beijing 100190, Peoples R China 6.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 7.Peking Univ, Biomed Inst Pioneering Invest Via Convergence, Beijing 100871, Peoples R China 8.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China 9.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 10.Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Weiqi,Zhang, Shu,Yan, Pengze,et al. A single-cell transcriptomic landscape of primate arterial aging[J]. NATURE COMMUNICATIONS,2020,11(1):13.
APA	Zhang, Weiqi.,Zhang, Shu.,Yan, Pengze.,Ren, Jie.,Song, Moshi.,...&Qu, Jing.(2020).A single-cell transcriptomic landscape of primate arterial aging.NATURE COMMUNICATIONS,11(1),13.
MLA	Zhang, Weiqi,et al."A single-cell transcriptomic landscape of primate arterial aging".NATURE COMMUNICATIONS 11.1(2020):13.