Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment

doi:10.3174/ajnr.A5587

	Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment
	Pang, R.4,7; Guo, R.6; Wu, X.5; Hu, F.2,3; Liu, M.7; Zhang, L.6; Wang, Z.7; Li, K.1,4,7
刊名	AMERICAN JOURNAL OF NEURORADIOLOGY
	2018-04-01
卷号	39 期号:4 页码:742-747
ISSN号	0195-6108
DOI	10.3174/ajnr.A5587
通讯作者	Li, K.(cjr.likuncheng@VIP.163.com)
英文摘要	BACKGROUND AND PURPOSE: Many studies have shown that insomnia is an independent factor in cognitive impairment, but the involved neurobiological mechanisms remain unclear. We used regional homogeneity to explore the specific neurobiologic indicators of chronic insomnia disorder with mild cognitive impairment. MATERIALS AND METHODS: Thirty-nine patients with insomnia were divided into a group with and without cognitive impairment; we also included a control group (n = 28). Abnormalities in brain functional activity were identified by comparing the regional homogeneity values for each brain region among the groups. RESULTS: Subjective insomnia scores were negatively correlated with cognitive impairment after controlling for age, sex, and educational effects. Regions with significant differences in regional homogeneity values in the 3 groups were concentrated in the right medial prefrontal cortex, the right superior frontal gyrus, and the left superior occipital gyrus. Meanwhile, subjective insomnia scores were negatively correlated with the strength of the decreased regional homogeneity in the right medial prefrontal cortex. The increased regional homogeneity value in the right superior frontal gyrus was positively correlated with the Montreal Cognitive Assessment score in patients. CONCLUSIONS: Our results indicate that decreased regional homogeneity values in the medial prefrontal cortex and increased regional homogeneity values in the cuneus may be important neurobiologic indicators of chronic insomnia disorder and accompanying cognitive impairment. Overall, our study described the regional homogeneity of the whole brain in chronic insomnia disorder with mild cognitive impairment and could be the basis for future studies.
资助项目	Beijing University of Chinese Medicine[2017-JYB-JS-166] ; National Natural Science Foundation of China[81471649] ; National Natural Science Foundation of China[81571648] ; National Natural Science Foundation of China[81370037]
WOS关键词	DEFAULT-MODE NETWORK ; STATE FUNCTIONAL MRI ; NREM SLOW WAVES ; SLEEP-DEPRIVATION ; OLDER-ADULTS ; MEMORY CONSOLIDATION ; NEURONAL PLASTICITY ; ALZHEIMERS-DISEASE ; DEPENDENT MEMORY ; PERFORMANCE
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	AMER SOC NEURORADIOLOGY
WOS记录号	WOS:000429745500022
资助机构	Beijing University of Chinese Medicine ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/28266]
专题	中国科学院自动化研究所
通讯作者	Li, K.
作者单位	1.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China 2.Harbin Univ Sci & Technol, Sch Automat, Harbin, Heilongjiang, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 5.Beijing Univ Chinese Med, Dongfang Hosp, Dept Acupuncture, Beijing, Peoples R China 6.Beijing Univ Chinese Med, Dongfang Hosp, Dept Neurol, Beijing, Peoples R China 7.Beijing Univ Chinese Med, Dongfang Hosp, Dept Radiol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Pang, R.,Guo, R.,Wu, X.,et al. Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2018,39(4):742-747.
APA	Pang, R..,Guo, R..,Wu, X..,Hu, F..,Liu, M..,...&Li, K..(2018).Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment.AMERICAN JOURNAL OF NEURORADIOLOGY,39(4),742-747.
MLA	Pang, R.,et al."Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment".AMERICAN JOURNAL OF NEURORADIOLOGY 39.4(2018):742-747.