Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer

doi:10.1016/j.biomaterials.2019.119264

	Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer
	Sun, Wei 1,2; Du, Yang 2,3; Liang, Xiaolong 4; Yu, Chunyao 1; Fang, Junjie 1; Lu, Wei 1; Guo, Xiuyu 1; Tian, Jie2,3,5,6 ; Jin, Yinhua 1; Zheng, Jianjun 1
刊名	BIOMATERIALS
	2019-10-01
卷号	217 页码:13
关键词	Breast cancer Polypyrrole nanoparticle Hyaluronic acid Photothermal therapy Triple-combination therapy
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2019.119264
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Jin, Yinhua(jyh-mri@163.com) ; Zheng, Jianjun(zhjjnb2@163.com)
英文摘要	Breast cancer is characterized by high aggression, poor prognosis, and high recurrence rate. Early detection and specific targeted treatment with less toxicity are the ultimate goals for breast cancer therapy. To improve antitumor therapeutic effects, we developed a novel polypyrrole nanoparticle using the near infrared dye IRDye800CW with camptothecin (CPT)-conjugated hyaluronic acid (HA) shell (PPy@CPT-HA-IRDye800CW) and performed a photothermal therapy (PTT), along with chemotherapy, guided by fluorescence and photo acoustic dual-modality imaging, in combination with immunotherapy. Irradiation with near infrared (NIR) light offered a strong PTT effect and promoted CPT drug release in tumors. Moreover, we found that chemo-photothermal therapy with PPy@CPT-HA-IRDye800CW NPs, in combination with immune checkpoint inhibitor anti-PD-L1 immunotherapy, synergistically enhanced the anti-tumor immune response, thereby eliminating primary breast cancer and preventing tumor metastases and recurrences in 4T1 tumor-bearing mice. This approach may provide important clues for the clinical management of breast cancer and other malignant tumors.
资助项目	National Key Research and Development Program of China, China[2017YFA0205200] ; National Natural Science Foundation of China, China[81871514] ; National Natural Science Foundation of China, China[81470083] ; National Natural Science Foundation of China, China[81227901] ; National Natural Science Foundation of China, China[81571810] ; National Natural Science Foundation of China, China[81771846] ; National Natural Science Foundation of China, China[81822022] ; Chinese Academy of Sciences, China[XDB02060010] ; International Innovation Team of CAS, China[20140491524] ; Beijing Municipal Commission of Science & Technology, China[Z161100002616022] ; Science Research Fund of National Health and Family Planning Commission Major Project of Medical and Health Science and Technology in Zhejiang Province, China[WKJ-ZJ-1807] ; Key R&D project of Zhejiang Province, China[2017C03042] ; Peking University Third Hospital, China[BYSY2015023]
WOS关键词	IMMUNE CHECKPOINT BLOCKADE ; INFRARED PHOTOTHERMAL THERAPY ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; EXPRESSION ; IMMUNOTHERAPY ; INDUCTION ; EFFICIENT ; DISEASE ; PD-L1
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000477786200014
资助机构	National Key Research and Development Program of China, China ; National Natural Science Foundation of China, China ; Chinese Academy of Sciences, China ; International Innovation Team of CAS, China ; Beijing Municipal Commission of Science & Technology, China ; Science Research Fund of National Health and Family Planning Commission Major Project of Medical and Health Science and Technology in Zhejiang Province, China ; Key R&D project of Zhejiang Province, China ; Peking University Third Hospital, China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/27803]
专题	中国科学院自动化研究所
通讯作者	Tian, Jie; Jin, Yinhua; Zheng, Jianjun
作者单位	1.Univ Chinese Acad Sci, Dept Radiol, Hwa Mei Hosp, Ningbo 2 Hosp, 41 Xibei St, Ningbo 315010, Zhejiang, Peoples R China 2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing 100191, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China 6.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Sun, Wei,Du, Yang,Liang, Xiaolong,et al. Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer[J]. BIOMATERIALS,2019,217:13.
APA	Sun, Wei.,Du, Yang.,Liang, Xiaolong.,Yu, Chunyao.,Fang, Junjie.,...&Zheng, Jianjun.(2019).Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer.BIOMATERIALS,217,13.
MLA	Sun, Wei,et al."Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer".BIOMATERIALS 217(2019):13.