Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis

doi:10.1021/acsnano.9b01979

	Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis
	Liu, Xiaoli 1,3; Zheng, Jianjun 6; Sun, Wei 6; Zhao, Xiao 1; Li, Yao 1; Gong, Ningqiang 1; Wang, Yanyun 3; Ma, Xiaowei 1; Zhang, Tingbin 5; Zhao, Ling-Yun 7
刊名	ACS NANO
	2019-08-01
卷号	13 期号:8 页码:8811-8825
关键词	ferrimagnetic vortex-domain iron oxide nanorings mild magnetic hyperthermia PD-L1 blockade immunotherapy immunological effect cancer metastasis
ISSN号	1936-0851
DOI	10.1021/acsnano.9b01979
通讯作者	Du, Yang(yang.du@ia.ac.cn) ; Fan, Haiming(fanhm@nwu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Liang, Xing-Jie(liangxj@nanoctr.cn)
英文摘要	Cancer metastasis is a serious concern and a major reason for treatment failure. Herein, we have reported the development of an effective and safe nanotherapeutic strategy that can eradicate primary tumors, inhibit metastasizing to lung, and control the metastasis and growth of distant tumors. Briefly, ferrimagnetic vortex-domain iron oxide nanoring (FVIO)-mediated mild magnetic hyperthermia caused calreticulin (CRT) expression on the 4T1 breast cancer cells. The CRT expression transmitted an "eat-me" signal and promoted phagocytic uptake of cancer cells by the immune system to induce an efficient immunogenic cell death, further leading to the macrophage polarization. This mild thermotherapy promoted 88% increase of CD8(+) cytotoxic T lymphocyte infiltration in distant tumors and triggered immunotherapy by effectively sensitizing tumors to the PD-L1 checkpoint blockade. The percentage of CD8(+) cytotoxic T lymphocytes can be further increased from 55.4% to 64.5% after combining with PD-L1 blockade. Moreover, the combination treatment also inhibited the immunosuppressive response of the tumor, evidenced by significant down-regulation of myeloid-derived suppressor cells (MDSCs). Our results revealed that the FWD-mediated mild magnetic hyperthermia can activate the host immune systems and efficiently cooperate with PD-L1 blockade to inhibit the potential metastatic spreading as well as the growth of distant tumors.
资助项目	Natural Science Foundation[31630027] ; Natural Science Foundation[31430031] ; NSFC-DFG[31761133013] ; Ministry of Science and Technology of China[2017YFA0205200] ; CAS[XDA09030301] ; National Natural Science Foundation of China[81571809] ; National Natural Science Foundation of China[81771981] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81227901]
WOS关键词	TUMOR-INFILTRATING LYMPHOCYTES ; IMMUNE CHECKPOINT BLOCKADE ; NEGATIVE BREAST-CANCER ; IRON-OXIDE NANOCUBES ; PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; ANTITUMOR IMMUNITY ; PROSTATE-CANCER ; NANOPARTICLES ; IMMUNOTHERAPY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000484077800031
资助机构	Natural Science Foundation ; NSFC-DFG ; Ministry of Science and Technology of China ; CAS ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/27341]
专题	中国科学院自动化研究所
通讯作者	Du, Yang; Fan, Haiming; Tian, Jie; Liang, Xing-Jie
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11,First North Rd, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Northwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 5.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China 6.Univ Chinese Acad Sci, Ningbo 2 Hosp, Hwa Mei Hosp, Dept Radiol, Ningbo 315010, Zhejiang, Peoples R China 7.Tsinghua Univ, Sch Mat Sci & Engn, Key Lab Adv Mat, Beijing 100084, Peoples R China 8.Nanjing Univ, Med Sch, Div Immunol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China 9.Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China 10.Zhejiang Hosp, Dept Radiat Oncol, Hangzhou 310013, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiaoli,Zheng, Jianjun,Sun, Wei,et al. Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis[J]. ACS NANO,2019,13(8):8811-8825.
APA	Liu, Xiaoli.,Zheng, Jianjun.,Sun, Wei.,Zhao, Xiao.,Li, Yao.,...&Liang, Xing-Jie.(2019).Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis.ACS NANO,13(8),8811-8825.
MLA	Liu, Xiaoli,et al."Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis".ACS NANO 13.8(2019):8811-8825.