Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks

doi:10.1016/j.neuroscience.2019.05.011

	Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks
	Niu, Weikun1,2,4,5 ; Huang, Xuhui1,2,3,4 ; Xu, Kaibin1,2,4,5 ; Jiang, Tianzi1,2,4,5 ; Yu, Shan1,2,4,5
刊名	NEUROSCIENCE
	2019-08-01
卷号	412 页码:190-206
关键词	task state fMRI pairwise correlation functional network neural network model
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2019.05.011
通讯作者	Yu, Shan(shan.yu@nlpr.ia.ac.cn)
英文摘要	Spatially separated brain areas interact with each other to form networks with coordinated activities, supporting various brain functions. Interaction structures among brain areas have been widely investigated through pairwise measures. However, interactions among multiple (e.g., triple and quadruple) areas cannot be reduced to pairwise interactions. Such higher order interactions (HOIs), e.g., exclusive-or (XOR) operation, are widely implemented in computation systems and are crucial for effective information processing. However, it is currently unclear whether any HOIs are present in large-scale brain functional networks when subjects are executing specific tasks. Here we analyzed functional magnetic resonance imaging (fMRI) data collected from human subjects executing various perceptual, motor, and cognitive tasks. We found that HOI strength in the macroscopic functional networks was very weak for all tasks, suggesting that major brain activities do not rely on HOIs on the macroscopic level at the timescale of hundreds of milliseconds. These weak HOIs during tasks were further investigated with a neural network model activated by external inputs, which suggested that weak pairwise interactions among brain areas organized the system without involving HOIs. Taken together, these results demonstrated the dominance of pairwise interactions in organizing coordinated activities among different brain areas to support various brain functions. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
资助项目	National Key Research and Development Program of China[2017YFA0105203] ; Natural Science Foundation of China[81471368] ; Natural Science Foundation of China[11505283] ; Natural Science Foundation of China[91732305] ; Natural Science Foundation of China[31620103905] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB32040200] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB32030200] ; Hundred-Talent Program of CAS ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SMC019]
WOS关键词	HIGHER-ORDER INTERACTIONS ; NETWORKS ; CORTEX ; MICROSTIMULATION ; INTEGRATION ; COMPETITION ; MECHANISM ; COHERENCE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000474688600016
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) ; Hundred-Talent Program of CAS ; Key Research Program of Frontier Sciences, CAS
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/26843]
专题	中国科学院自动化研究所
通讯作者	Yu, Shan
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Niu, Weikun,Huang, Xuhui,Xu, Kaibin,et al. Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks[J]. NEUROSCIENCE,2019,412:190-206.
APA	Niu, Weikun,Huang, Xuhui,Xu, Kaibin,Jiang, Tianzi,&Yu, Shan.(2019).Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks.NEUROSCIENCE,412,190-206.
MLA	Niu, Weikun,et al."Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks".NEUROSCIENCE 412(2019):190-206.