Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle

doi:10.1002/ppsc.201900085

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle
	Hu, Min 1,2,3,4; Wang, Kun2,4 ; Shang, Wenting2,4 ; Han, Ziyu 1,5; Jiang, Hongmei 2; Fang, Chihua 1,5; Tian, Jie2,4
刊名	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
	2019-08-01
卷号	36 期号:8 页码:12
关键词	fluorescence-guided surgery hepatocellular carcinoma intraoperative photothermal therapy triple-modality imaging
ISSN号	0934-0866
DOI	10.1002/ppsc.201900085
通讯作者	Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要	Hepatectomy is one of the main treatments for hepatocellular carcinoma (HCC). However, because microscopic tumor residues are often present after surgery, the recurrence rate of HCC remains extremely high. A multimodality imaging-guided multifunctional nanoparticle, indocyanine-green-gadolinium-copper sulfide@bovine-serum-albumin-epithelial-cell-adhesion molecule (EpCAM), is developed for HCC treatment based on a novel theranostic strategy. After intravenous injection of these nanoparticles into HCC-bearing mice, remarkably selective accumulation and highly efficient retention of the nanoparticles in tumor sites are observed. This is due to the EpCAM's specific targeting ability, which also results in enhanced HCC contrast in a tri-modal visualization, which unites magnetic resonance, photoacoustic, and fluorescence imaging. Moreover, nanoparticle uptake into the HCC allows photothermal therapy (PTT) as an interoperative adjuvant strategy for further eliminating possible microscopic residues and boosting HCC surgery outcomes. This theranostic strategy not only helps with precise diagnosis of HCC but enables intraoperatively imaging guidance for accurate tumor resection. Moreover, postoperation longitudinal observation demonstrates that intraoperative imaging-guided resection alongside a PTT-integrated treatment strategy can result in a significant improvement of overall survival rate. These multifunctional EpCAM-targeting nanoparticles may respresent a novel theranostic strategy to improve postsurgical HCC treatment.
WOS关键词	PHOTOTHERMAL THERAPY ; CANCER STATISTICS ; REAL-TIME ; ALBUMIN ; RECURRENCE ; CELLS ; IDENTIFICATION ; TOMOGRAPHY ; RESECTION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000482449300007
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25833]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Fang, Chihua; Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510630, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Inst Automat, Beijing 100080, Peoples R China 5.Res Ctr Digital Med, Guangdong Prov Clin & Engn Technol, Guangzhou 510280, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Hu, Min,Wang, Kun,Shang, Wenting,et al. Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2019,36(8):12.
APA	Hu, Min.,Wang, Kun.,Shang, Wenting.,Han, Ziyu.,Jiang, Hongmei.,...&Tian, Jie.(2019).Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,36(8),12.
MLA	Hu, Min,et al."Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 36.8(2019):12.