Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis

doi:10.1021/acs.nanolett.8b05202

	Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis
	Xu, Jinshun 1,2,3; Chen, Xueqing 5; Tan, Longfei 2; Fu, Changhui 2; Ahmed, Muneeb 4; Tian, Jie6 ; Dou, Jianping 1; Zhou, Qunfang 1; Ren, Xiangling 2; Wu, Qiong 2
刊名	NANO LETTERS
	2019-05-01
卷号	19 期号:5 页码:2914-2927
关键词	Nanoplatform P-selectin microwave hepatocellular carcinoma metastasis
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.8b05202
通讯作者	Meng, Xianwei(mengxw@mail.ipc.ac.cn) ; Yu, Jie(yu-jie301@hotmail.com) ; Liang, Ping(liangping301@hotmail.com)
英文摘要	Hepatocellular carcinoma (HCC) with metastatic disease is associated with a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective in local but limited for patients with distant metastasis. In this study, the efficacy, specificity, and safety of P-selectin targeted delivery and microwave (MW) responsive drug release is investigated for development of HCC therapy. By encapsulating doxorubicin (DOX) and MW sensitizer (1-butyl-3-methylimidazolium-L-lactate, BML) into fucoidan conjugated liposomal nanoparticles (TBP@DOX), specific accumulation and prominent release of DOX in orthotopic HCC and lung metastasis are achieved with adjuvant MW exposure. This results in orthotopic HCC growth inhibition that is not only 1.95-fold higher than found for nontargeted BP@DOX and 1.6-fold higher than nonstimuli responsive TP@DOX but is also equivalent to treatment with free DOX at a 10-fold higher dose. Furthermore, the optimum anticancer efficacy against distant lung metastasis and effective prevention of widespread dissemination with a prolonged survival is described. In addition, no adverse metabolic events are identified using the TBP@DOX nanodelivery system despite these events being commonly observed with traditional DOX chemotherapy. Therefore, administering TBP@DOX with MW exposure could potentially enhance the therapeutic efficacy of thermal-chemotherapy of HCC, especially those in the advanced stages.
资助项目	National Key R&D Program of China[2017YFC0112000] ; National Natural Science Foundation of China (NSFC)[81627803] ; National Natural Science Foundation of China (NSFC)[91859201] ; National Natural Science Foundation of China (NSFC)[81622024] ; National Natural Science Foundation of China (NSFC)[81701797] ; Beijing Natural Science Foundation[JQ18021] ; Beijing Natural Science Foundation[7192200] ; Beijing Natural Science Foundation[4161003]
WOS关键词	CANCER STATISTICS ; TUMOR ; NANOPARTICLES ; NANOCARRIERS ; STRATEGIES ; SORAFENIB ; PLATFORM ; THERAPY ; LIGANDS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000467781900020
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/24203]
专题	中国科学院自动化研究所
通讯作者	Meng, Xianwei; Yu, Jie; Liang, Ping
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen, Beijing 100190, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China 4.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Radiol, Lab Minimally Invas Tumor Therapies, Boston, MA 02215 USA 5.Sichuan Prov Canc Hosp, Dept Ultrasound, Chengdu 610041, Peoples R China 6.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jinshun,Chen, Xueqing,Tan, Longfei,et al. Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis[J]. NANO LETTERS,2019,19(5):2914-2927.
APA	Xu, Jinshun.,Chen, Xueqing.,Tan, Longfei.,Fu, Changhui.,Ahmed, Muneeb.,...&Liang, Ping.(2019).Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis.NANO LETTERS,19(5),2914-2927.
MLA	Xu, Jinshun,et al."Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis".NANO LETTERS 19.5(2019):2914-2927.