Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects

doi:10.1016/j.nicl.2017.10.038

	Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects
	Liu, Shuai 1; Wang, Yinyan 1; Xu, Kaibin2,3,4 ; Ping, Fan 5,6; Li, Fang 6,7; Wang, Renzhi 6,8; Cheng, Xin 6,7
刊名	NEUROIMAGE-CLINICAL
	2018
卷号	17 页码:354-358
关键词	Cushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis
DOI	10.1016/j.nicl.2017.10.038
文献子类	Article
英文摘要	Cognitive impairment and psychiatric symptoms are common in patients with Cushing's disease (CD) owing to elevated levels of glucocorticoids. Molecular neuroimaging methods may help to detect changes in the brain of patients with CD. The aim of this study was to investigate the characteristics of brain metabolism and its association with serum cortisol level in CD. We compared brain metabolism, as measured using [F-18]-fluorodeoxyglucose positron emission tomography (FDG PET), between 92 patients with CD and 118 normal subjects on a voxel-wise basis. Pearson correlation was performed to evaluate the association between cerebral FDG uptake and serum cortisol level in patients with CD. We demonstrated that certain brain regions in patients with CD showed significantly increased FDG uptake, including the basal ganglia, anteromedial temporal lobe, thalamus, precentral cortex, and cerebellum. The clusters that demonstrated significantly decreased uptake were mainly located in the medial and lateral frontal cortex, superior and inferior parietal lobule, medial occipital cortex, and insular cortex. The metabolic rate of the majority of these regions was found to be significantly correlated with the serum cortisol level. Our findings may help to explain the underlying mechanisms of cognitive impairment and psychiatric symptoms in patients exposed to excessive glucocorticoids and evaluate the efficacy of treatments during follow-up.
WOS关键词	PITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; LONG-TERM REMISSION ; QUALITY-OF-LIFE ; CORTISOL-LEVELS ; LIMBIC SYSTEM ; STRESS ; VOLUME ; HIPPOCAMPUS ; IMPROVEMENT
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000426180300038
资助机构	National Natural Science Foundation of China(81201121) ; Beijing Postdoctoral Research Foundation(2017-ZZ-116)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/21973]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China 6.Peking Union Med Coll, Beijing 100730, Peoples R China 7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China 8.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects[J]. NEUROIMAGE-CLINICAL,2018,17:354-358.
APA	Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Li, Fang.,...&Cheng, Xin.(2018).Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects.NEUROIMAGE-CLINICAL,17,354-358.
MLA	Liu, Shuai,et al."Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects".NEUROIMAGE-CLINICAL 17(2018):354-358.