Dynamic default mode network connectivity diminished in patients with schizophrenia

	Dynamic default mode network connectivity diminished in patients with schizophrenia
	Yuhui Du; Hao He; Lei Wu; Qingbao Yu; Sui Jing(隋婧); Vince D. Calhoun
	2015
会议日期	23 July 2015
会议地点	New York, NY, USA
关键词	Dynamic Functional Network Default Mode Network Functional Magnetic Resonance Imaging Schizophrenia
英文摘要	Recent works have shown that, even in resting state, functional networks undergo dynamic changes over short time. In this study, we describe an approach to assess the difference in default mode network (DMN) dynamics between healthy controls (HC) and schizophrenia patients (SZ) using resting-state functional magnetic resonance imaging. Firstly, dynamic DMN was computed using a sliding time window method. Then, stability of the dynamic DMN evaluated using the spectrum of time-varying functional connectivity was compared between HC and SZ. Subsequently, the overall functional connectivity pattern and dynamic graph measures were also investigated for both groups. Results show that dynamic DMN of HC had more stable and stronger functional connectivity than that of SZ. Regarding to dynamic graph measures, SZ had lower connectivity strength, clustering coefficient, global efficiency, and local efficiency than HC. The findings suggest that dynamic functional network analysis is a promising technique for understanding schizophrenia.
内容类型	会议论文
源URL	[http://ir.ia.ac.cn/handle/173211/20303]
专题	自动化研究所_脑网络组研究中心
推荐引用方式 GB/T 7714	Yuhui Du,Hao He,Lei Wu,et al. Dynamic default mode network connectivity diminished in patients with schizophrenia[C]. 见:. New York, NY, USA. 23 July 2015.