Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor

doi:10.1016/j.nano.2017.02.014

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor
	Shen, Song 1; Ding, Bei 1; Zhang, Shengchang 1; Qi, Xueyong 1; Wang, Kun4 ; Tian, Jie4 ; Yan, Yongsheng 3; Ge, Yanru 1; Wu, Lin 2
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2017-07-01
卷号	13 期号:5 页码:1607-1616
关键词	Photoacoustic Imaging Magnetic Iron Oxide Thermoresponsive Photothermal Therapy Targeting Drug Delivery
DOI	10.1016/j.nano.2017.02.014
文献子类	Article
英文摘要	Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticle cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs. In vivo fluorescence/photoacoustic images demonstrated that Fe3O4-PNIPAM nanoparticles could accumulate in the tumor after intravenous injection. Upon the irradiation of the NIR laser, DOX-Fe3O4-PNIPAM nanoparticles exhibited outstanding synergistic effect. The tumor inhibition rate increased from 40.3% (DOX-Fe3O4-PNIPAM alone) and 65.2% (Fe3O4-PNIPAM +NIR) to 91.5%. The results demonstrated that the NIR-responsive nanocarrier offers a novel strategy for cancer theranostics and combined therapy of cancer. (C) 2017 Elsevier Inc. All rights reserved.
WOS关键词	IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; CANCER-THERAPY ; LOW TOXICITY ; CHEMOTHERAPY ; HYPERTHERMIA ; GRAPHENE ; NANORODS
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
WOS记录号	WOS:000403662500003
资助机构	National Natural Science Foundation of China(81172999 ; Natural Science Foundation of Jiangsu Province(BK20150534) ; Senior Talent Foundation of Jiangsu University(14JDG181) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; China Postdoctoral Science Foundation(2015 M580404) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1402075B) ; 81503017)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/15129]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang, Peoples R China 2.Jiangsu Univ, Dept Clin Pharm, Affiliated Hosp, Zhenjiang, Peoples R China 3.Jiangsu Univ, Inst Green Chem & Chem Technol, Zhenjiang, Peoples R China 4.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Shen, Song,Ding, Bei,Zhang, Shengchang,et al. Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(5):1607-1616.
APA	Shen, Song.,Ding, Bei.,Zhang, Shengchang.,Qi, Xueyong.,Wang, Kun.,...&Wu, Lin.(2017).Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(5),1607-1616.
MLA	Shen, Song,et al."Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.5(2017):1607-1616.