In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography

doi:10.2967/jnumed.116.180596

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography
	Hu, Zhenhua1,2 ; Zhao, Mingxuan 3; Qu, Yawei 4; Zhang, Xiaojun 5; Zhang, Mingru 3; Liu, Muhan 1; Guo, Hongbo 1; Zhang, Zeyu1 ; Wang, Jing 3; Yang, Weidong 3
刊名	JOURNAL OF NUCLEAR MEDICINE
	2017
卷号	58 期号:1 页码:169-174
关键词	Radiopharmaceutical Excitation Fluorescence Tomography (Reft) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Pet
DOI	10.2967/jnumed.116.180596
文献子类	Article
英文摘要	Cerenkov luminescence imaging can image radiopharmaceuticals using a high-sensitivity charge-coupled device camera. However, Cerenkov luminescence emitted from the radiopharmaceuticals is weak and has low penetration depth in biologic tissues, which severely limits the sensitivity and accuracy of Cerenkov luminescence imaging. This study presents 3-dimensional (3D) radiophamiaceutical-excited fluorescence tomography (REFT) using europium oxide (EO) nanoparticles, which enhances the Cerenkov luminescence signal intensity, improves the penetration depth, and obtains more accurate 3D distribution of radiopharmaceuticals. Methods: The enhanced optical signals of various radiopharmaceuticals (including F-18-FDG, (GaCl3)-Ga-68, Na(99)mTcO(4)) by EO nanoparticles were detected in vitro. The location and 3D distribution of the radiopharmaceuticals of REFT were then reconstructed and compared with those of Cerenkov luminescence tomography through the experiments with the phantom, artificial source-implanted mouse models, and mice bearing hepatocellular carcinomas. Results: The mixture of (GaCl3)-Ga-68 and EO nanoparticles possessed the strongest optical signals compared with the other mixtures. The in vitro phantom and implanted mouse studies showed that REFT revealed more accurate 3D distribution of (GaCl3)-Ga-68. REFT can detect more tumors than small-animal PET in hepatocellular carcinoma-bearing mice and achieved more accurate 3D distribution information than Cerenkov luminescence tomography. Conclusion: REFT with EO nanoparticles significantly improves accuracy of localization of radiopharmaceuticals and can precisely localize the tumor in vivo.
WOS关键词	CERENKOV LUMINESCENCE TOMOGRAPHY ; MOUSE MODEL ; RADIONUCLIDE ; ENDOSCOPY
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
WOS记录号	WOS:000391343400036
资助机构	National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; Beijing Municipal Science and Technology Commission(Z151100001615012) ; 81371594 ; 61231004 ; 81527805 ; 61302024 ; 81230033 ; 81471700)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/13387]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 4.Gen Hosp Chinese Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhenhua,Zhao, Mingxuan,Qu, Yawei,et al. In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography[J]. JOURNAL OF NUCLEAR MEDICINE,2017,58(1):169-174.
APA	Hu, Zhenhua.,Zhao, Mingxuan.,Qu, Yawei.,Zhang, Xiaojun.,Zhang, Mingru.,...&Tian, Jie.(2017).In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography.JOURNAL OF NUCLEAR MEDICINE,58(1),169-174.
MLA	Hu, Zhenhua,et al."In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography".JOURNAL OF NUCLEAR MEDICINE 58.1(2017):169-174.