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	Conservation and implications of eukaryote transcriptional regulatory regions across multiple species
	Wan, Lin ; Li, Dayong ; Zhang, Donglei ; Liu, Xue ; Fu, Wenjiang J. ; Zhu, Lihuang ; Deng, Minghua ; Sun, Fengzhu ; Qian, Minping
	2010-10-12 ; 2010-10-12
关键词	FACTOR-BINDING-SITES RNA-POLYMERASE-II HUMAN GENOME SEQUENCE-ANALYSIS CORE PROMOTERS MIRNA GENES DNA IDENTIFICATION ARABIDOPSIS DISCOVERY Biotechnology & Applied Microbiology Genetics & Heredity
中文摘要	Background: Increasing evidence shows that whole genomes of eukaryotes are almost entirely transcribed into both protein coding genes and an enormous number of non-protein-coding RNAs (ncRNAs). Therefore, revealing the underlying regulatory mechanisms of transcripts becomes imperative. However, for a complete understanding of transcriptional regulatory mechanisms, we need to identify the regions in which they are found. We will call these transcriptional regulation regions, or TRRs, which can be considered functional regions containing a cluster of regulatory elements that cooperatively recruit transcriptional factors for binding and then regulating the expression of transcripts. Results: We constructed a hierarchical stochastic language (HSL) model for the identification of core TRRs in yeast based on regulatory cooperation among TRR elements. The HSL model trained based on yeast achieved comparable accuracy in predicting TRRs in other species, e. g., fruit fly, human, and rice, thus demonstrating the conservation of TRRs across species. The HSL model was also used to identify the TRRs of genes, such as p53 or OsALYLI, as well as microRNAs. In addition, the ENCODE regions were examined by HSL, and TRRs were found to pervasively locate in the genomes. Conclusion: Our findings indicate that 1) the HSL model can be used to accurately predict core TRRs of transcripts across species and 2) identified core TRRs by HSL are proper candidates for the further scrutiny of specific regulatory elements and mechanisms. Meanwhile, the regulatory activity taking place in the abundant numbers of ncRNAs might account for the ubiquitous presence of TRRs across the genome. In addition, we also found that the TRRs of protein coding genes and ncRNAs are similar in structure, with the latter being more conserved than the former.
语种	英语 ; 英语
出版者	BIOMED CENTRAL LTD ; LONDON ; CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/82215]
专题	清华大学
推荐引用方式 GB/T 7714	Wan, Lin,Li, Dayong,Zhang, Donglei,et al. Conservation and implications of eukaryote transcriptional regulatory regions across multiple species[J],2010, 2010.
APA	Wan, Lin.,Li, Dayong.,Zhang, Donglei.,Liu, Xue.,Fu, Wenjiang J..,...&Qian, Minping.(2010).Conservation and implications of eukaryote transcriptional regulatory regions across multiple species..
MLA	Wan, Lin,et al."Conservation and implications of eukaryote transcriptional regulatory regions across multiple species".(2010).

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