Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality

	Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
	Zang, YF ; Jin, Z ; Weng, XC ; Zhang, L ; Zeng, YW ; Yang, L; Wang, YF ; Seidman, LJ ; Faraone, SV
刊名	BRAIN & DEVELOPMENT
	2005-12-01
卷号	27 期号:8 页码:544-550
关键词	attention-deficit hyperactivity disorder functional magnetic resonance imaging Stroop effect hypofrontality methylphenidate compensation
英文摘要	Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	BASAL GANGLIA VOLUMES ; MAGNETIC-RESONANCE ; DEFICIT/HYPERACTIVITY DISORDER ; CEREBELLAR ; CHILDREN ; METHYLPHENIDATE ; ADHD ; SCHIZOPHRENIA ; RELAXOMETRY ; ADOLESCENTS
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000234199200002
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/9115]
专题	自动化研究所_09年以前成果
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China 4.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA 5.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA 6.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA 7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA 8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
APA	Zang, YF.,Jin, Z.,Weng, XC.,Zhang, L.,Zeng, YW.,...&Faraone, SV.(2005).Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality.BRAIN & DEVELOPMENT,27(8),544-550.
MLA	Zang, YF,et al."Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality".BRAIN & DEVELOPMENT 27.8(2005):544-550.