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厦门大学 [2]
上海药物研究所 [2]
大连化学物理研究所 [1]
武汉物理与数学研究所 [1]
中南大学 [1]
长春应用化学研究所 [1]
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期刊论文 [9]
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2021 [1]
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2012 [1]
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物理化学与绿色催化 [1]
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Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products
期刊论文
ACS CATALYSIS, 2021, 卷号: 11, 期号: 3, 页码: 1758-1764
作者:
Xu, Hui
;
Ma, Biao
;
Fu, Zunyun
;
Li, Han-Yuan
;
Wang, Xing
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
alkynylation
Ar-C(O) cleavage
ligand
palladium
late-stage diversification
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
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  |  
浏览/下载:259/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Ar-BINMOL-DERIVED SALAN-Cu(II) COMPLEX-CATALYZED SILYL-REFORMATSKY REACTION OF AROMATIC ALDEHYDES
期刊论文
Synthetic Communications, 2014, 卷号: 44, 期号: 19, 页码: 2861-2869
作者:
Li F(李菲)
;
Zhou, Wei
;
Zheng LS(郑龙生)
;
Li L(李莉)
;
Zheng ZJ(郑战江)
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  |  
浏览/下载:26/0
  |  
提交时间:2016/02/15
Ar-BINMOL
aromatic aldehydes
organosilicon chemistry
Reformatsky reaction
salan ligand
Synthesis, characterization, and ethylene polymerization behaviors of late-transition metal complexes coordinated with chlorinated bis(arylimino)pyridine ligand
期刊论文
polymer, 2014, 卷号: 55, 期号: 18, 页码: 4611-4618
Liu, Heng
;
Wang, Feng
;
Liu, Li
;
Jai,Xiang-Yu
;
Zheng,Wenjie
;
Guo,Jun
;
Zhang,Chun-Yu
;
Bai,Chen-Xi
;
Hu,Yan-Ming
;
Zhang,Xue-Quan
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  |  
浏览/下载:20/0
  |  
提交时间:2015/10/20
A series of late-transition metal complexes supported with chlorinated bis(arylimino)pyridine ligands [2
Ar = 2
Ar = 2
Ar = 2
Ar = 4-Cl-2
Ar = 4-Br-2
6-(ArN=CCl)(2)C5H3N]MtCl(2) (Ar = 2
6-(Pr2C6H3)-Pr-i
6-Et2C6H3
6-Me2C6H3
6-Me2C6H2
6-Me2C6H2
4
Mt = Fe (1b)
Mt = Co (1c)
Mt = Fe (1d)
Mt = Fe (1e)
Mt = Fe (1f)
6-Me3C6H2
Co (2b)
Ni (3c)
Co (2d)
Co (2e)
Co (2f)) were synthesized. At the presence of methylaluminoxane (MAO)
Mt = Fe (1a)
Fe(II)- and Co(II)- based complexes were highly active towards ethylene polymerization
Co (2a)
affording polymers with bimodal and unimodal molar. mass distributions
Ni (3a)
respectively
while the Ni(II)-based complexes gave no polymer products. Moreover
the obtained polyethylenes were predominately saturated and vinyl-terminated for Fe(II)- and Co(II)-based complexes
respectively. Changing the ligand environment
polymerization parameters also posed a great influence on the catalytic activities and the properties of the resulting polymers. (C) 2014 Elsevier Ltd. All rights reserved.
Antagonist binding and induced conformational dynamics of GPCR A(2A) adenosine receptor
期刊论文
proteins-structure function and bioinformatics, 2013, 卷号: 81, 期号: 8, 页码: 1399-1410
作者:
Pang, Xueqin
;
Yang, Mingjun
;
Han, Keli
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2015/11/09
A(2A)AR
molecular dynamics
ZM241385
KW6002
ligand specific binding
ionic lock
rotamer toggle switch
secondary structure
beta-Diketiminate Germylene-Supported Pentafluorophenylcopper(I) and -silver(I) Complexes [LGe(Me)(CuC6F5)(n)](2) (n=1, 2), LGe[C(SiMe3)N-2]AgC6F5, and {LGe[C(SiMe3)N-2](AgC6F5)(2)}(2) (L = HC[C(Me)N-2,6-iPr(2)C(6)H(3)](2)): Synthesis and Structural Characterization
期刊论文
2012
Zhao, Na
;
Zhang, Jinyuan
;
Yang, Ying
;
Zhu, Hongping
;
Li, Yan
;
Fu, Gang
;
傅钢
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2013/02/25
N-HETEROCYCLIC CARBENE
UNSUPPORTED SILVER-GERMANIUM
COPPER(I) ALKYL COMPLEXES
PI-STACKING INTERACTIONS
GROUP-16 ELEMENTS
REACTIVITY
CHEMISTRY
LIGAND
AR=2,6-IPR(2)C(6)H(3)
AU
Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus
期刊论文
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 8, 页码: 1038
作者:
Liu Zhenjia
;
Yang Yanjuan
;
Jiang Lei
;
Xu Yingchun
;
Wang Aixia
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/12/24
CHEMOKINE RECEPTORS
LIGAND-BINDING
ANAPHYLATOXIN
RECOGNITION
RESIDUES
C5L2
Staphylococcus aureus
chemotaxis inhibitory protein
tyrosine sulfation
post-translational modification
chemotactic receptor
C5aR
Synthesis, structure, and reactivity of beta-diketiminate complexes of manganese(II)
期刊论文
2004
Chai, J. F.
;
Zhu, H. P.
;
Roesky, H. W.
;
He, C.
;
Schmidt, H. G.
;
Noltemeyer, M.
;
朱红平
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2013/12/12
MN-II
LIGAND
3-COORDINATE
AR=2,6-IPR(2)C(6)H(3)
DERIVATIVES
MAGNETISM
CARBENE
CORE
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