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科研机构
西北高原生物研究所 [2]
上海药物研究所 [1]
武汉物理与数学研究所 [1]
山东大学 [1]
中南大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [7]
发表日期
2019 [1]
2018 [1]
2017 [2]
2012 [3]
学科主题
生物科学 [1]
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Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:259/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Platelets Express Activated P2Y(12) Receptor in Patients With Diabetes Mellitus
期刊论文
CIRCULATION, 2017, 卷号: 136, 期号: 9, 页码: 817-U102
作者:
Hu, Liang
;
Chang, Lin
;
Zhang, Yan
;
Zhai, Lili
;
Zhang, Shenghui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
antiplatelet
antithrombotic
AR-C78511
cangrelor
inverse agonist
P2Y(12)
P2Y(12) receptor antagonist
type 2 diabetes mellitus
Platelets Express Activated P2Y(12) Receptor in Patients With Diabetes Mellitus
期刊论文
CIRCULATION, 2017, 卷号: 136, 期号: 9
作者:
Hu, Liang
;
Chang, Lin
;
Zhang, Yan
;
Zhai, Lili
;
Zhang, Shenghui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
antiplatelet
antithrombotic
AR-C78511
cangrelor
inverse agonist
P2Y(12)
P2Y(12) receptor antagonist
type 2 diabetes mellitus
Activation of beta(2)-Adrenergic Receptor Induced by Three Catecholamine Agonists: a Docking and Molecular Dynamics Study
期刊论文
chemical research in chinese universities, 2012, 卷号: 28, 期号: 3, 页码: 493-499
作者:
Zhang Rui
;
Dong Li-hua
;
Ling Bao-ping
;
Wang Zhi-guo
;
Liu Yong-jun
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2013/03/15
beta(2)-Adrenergic receptor(beta(2)AR)
G Protein coupled receptor(GPCR)
Molecular dynamics
Agonist
Activation
Activation of β2-Adrenergic Receptor Induced by Three Catecholamine Agonists: a Docking and Molecular Dynamics Study
期刊论文
CHEM. RES. CHINESE UNIVERSITIES, 2012, 卷号: 28, 期号: 3, 页码: 493-499
ZHANG Rui
;
DONG Li-hua
;
LING Bao-ping
;
WANG Zhi-guo
;
LIU Yong-jun
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2012/11/26
β2-Adrenergic receptor(β2AR)
G Protein coupled receptor(GPCR)
Molecular dynamics
Agonist
Activation
Activation of beta(2)-Adrenergic Receptor Induced by Three Catecholamine Agonists: a Docking and Molecular Dynamics Study
期刊论文
高等学校化学研究(英文版), 2012, 卷号: 28, 期号: 3, 页码: 493-499
作者:
Zhang Rui
;
Dong Li-hua
;
Ling Bao-ping
;
Wang Zhi-guo
;
Liu Yong-jun
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
β2-Adrenergic receptor(β2AR)
G Protein coupled receptor(GPCR)
Molecular dynamics
Agonist
Activation
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