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科研机构
上海药物研究所 [55]
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期刊论文 [52]
会议论文 [3]
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Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:
Zhou, Yan
;
Du, Dao-Hai
;
Wang, Jia
;
Cai, Xiao-Qing
;
Deng, Alicia X.
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2020/07/01
embryonic ectoderm development
Enhancer of zeste homolog 2
fluorescence polarization
high-throughput screening
homogenous time-resolved fluorescence
inhibitor
polycomb repressive complex 2
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:
Qu, Chunrong
;
Ding, Mingmin
;
Zhu, Yingmin
;
Lu, Yungang
;
Du, Juan
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
Small molecule DCDBS84 regulates platelet thrombus formation by targeting C-SRC SH3 domain
会议论文
作者:
Long, Z.
;
Zhu, K.
;
Huang, J.
;
Shi, X.
;
Liu, J.
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Interaction Between DNA/histone Methyltransferases and their Inhibitors
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2015, 卷号: 22, 期号: 3, 页码: 360-372
作者:
Hu, J.
;
Chen, S.
;
Kong, X.
;
Zhu, K.
;
Cheng, S.
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
DNA methyltransferase
drug discovery
epigenetic therapy
histone methyltransferase
inhibitor
Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting
期刊论文
CHINESE JOURNAL OF CANCER, 2014, 卷号: 33, 期号: 12, 页码: 620-624
作者:
Luo, Feng Roger
;
Ding, Jian
;
Chen, Helen X.
;
Liu, Hao
;
Fung, Man-Cheong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Breakthrough
clinical trial
cancer medicine
Breakthrough cancer medicine and its impact on novel drug development in China:report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting
期刊论文
Chinese Journal of Cancer, 2014, 卷号: 33, 期号: 12, 页码: 620
作者:
Luo Feng Roger
;
Ding Jian
;
Chen Helen X
;
Liu Hao
;
Fung Mancheong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
CELL LUNG-CANCER
GASTRIC-CANCER
BREAST-CANCER
INHIBITOR
PCI-32765
IBRUTINIB
Breakthrough
clinical trial
cancer medicine
Computational Models for Predicting Interactions with Membrane Transporters
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2013, 卷号: 20, 期号: 16, 页码: 2118-2136
作者:
Xu, Y.
;
Shen, Q.
;
Liu, X.
;
Lu, J.
;
Li, S.
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Computational methods
homology modeling
membrane transporter
phamacophore models
QSAR models
supervised/unsupervised learning algorithms
The structure design and biological activities of inhibitory peptides, which block the interactions among polycomb repressive complex 2
会议论文
作者:
Li, K. K.
;
Luo, L.
;
Kong, X.
;
Li, L.
;
Luo, C.
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  |  
浏览/下载:5/0
  |  
提交时间:2019/01/08
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