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科研机构
上海药物研究所 [19]
内容类型
期刊论文 [18]
会议论文 [1]
发表日期
2021 [4]
2020 [2]
2019 [3]
2018 [2]
2016 [2]
2015 [1]
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Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
收藏
  |  
浏览/下载:145/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Structural basis of GPBAR activation and bile acid recognition
期刊论文
NATURE, 2020, 页码: 29
作者:
Yang, Fan
;
Mao, Chunyou
;
Guo, Lulu
;
Lin, Jingyu
;
Ming, Qianqian
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292
作者:
Zhang, Feng-cai
;
Sun, Zhong-ya
;
Liao, Li-ping
;
Zuo, Yu
;
Zhang, Dan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice
期刊论文
AGING-US, 2019, 卷号: 11, 期号: 23, 页码: 11084-11110
作者:
Li, Dan
;
Liu, Qianyu
;
Lu, Xiuqiang
;
Li, Zhengqiu
;
Wang, Chunming
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
alpha-mangostin
aging
adiposity
adipose tissue inflammation
macrophage
DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2019, 卷号: 51, 期号: 5, 页码: 517-523
作者:
Zhang, Ting
;
Li, Bo
;
Feng, Qilin
;
Xu, Zhijian
;
Huang, Cheng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
DCZ0801
multiple myeloma
apoptosis
cell cycle
MAPK
dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma
期刊论文
actabiochimicaetbiophysicasinica, 2019, 卷号: 51, 期号: 5, 页码: 517
作者:
Zhang Ting
;
Li Bo
;
Feng Qilin
;
Xu Zhijian
;
Huang Cheng
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
IN-VITRO
PTEROSTILBENE
CANCER
PROLIFERATION
P38
ACTIVATION
INDUCTION
SURVIVAL
ERK1/2
DCZ0801
multiple myeloma
apoptosis
cell cycle
MAPK
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
期刊论文
IMMUNITY, 2018, 卷号: 49, 期号: 4, 页码: 740-+
作者:
Deng, Meihong
;
Tang, Yiting
;
Li, Wenbo
;
Wang, Xiangyu
;
Zhang, Rui
收藏
  |  
浏览/下载:110/0
  |  
提交时间:2019/01/08
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