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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [9]
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2021 [1]
2020 [2]
2016 [1]
2014 [1]
2012 [1]
2011 [1]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106
作者:
Su, Haixia
;
Zou, Yi
;
Chen, Guofeng
;
Dou, Huixia
;
Xie, Hang
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
An optimization of the LC-MS/MS workflow for deep proteome profiling on an Orbitrap Fusion
期刊论文
ANALYTICAL METHODS, 2016, 卷号: 8, 期号: 2, 页码: 425-434
作者:
Nie, Litong
;
Zhu, Mingrui
;
Sun, Shengnan
;
Zhai, Linhui
;
Wu, Zhixiang
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Orally active-targeted drug delivery systems for proteins and peptides
期刊论文
EXPERT OPINION ON DRUG DELIVERY, 2014, 卷号: 11, 期号: 9, 页码: 1435-1447
作者:
Li, Xiuying
;
Yu, Miaorong
;
Fan, Weiwei
;
Gan, Yong
;
Hovgaard, Lars
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
active-targeted drug delivery systems
IgG-Fc receptor
intercellular adhesion molecule-1
oral protein and peptide delivery
proton-coupled folate transporter
recombinant fusion protein
transferrin receptor
Simultaneous Determination of Four Sesquiterpenoids in Atractylodes Macrocephala Rhizoma by GC-FID: Optimisation of an Ultrasound-assisted Extraction by Central Composite Design
期刊论文
PHYTOCHEMICAL ANALYSIS, 2012, 卷号: 23, 期号: 4, 页码: 408-414
作者:
Shi, Yang-Yang
;
Guan, Shu-Hong
;
Tang, Ren-Neng
;
Tao, Si-Jia
;
Guo, De-An
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  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Central composite design
gas chromatography-flame ionisation detector
quality control
sesquiterpenoids
Atractylodes Macrocephala Rhizoma
Bioreducible poly (beta-amino esters)/shRNA complex nanoparticles for efficient RNA delivery
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2011, 卷号: 151, 期号: 1, 页码: 35-44
作者:
Yin, Qi
;
Gao, Yu
;
Zhang, Zhiwen
;
Zhang, Pengcheng
;
Li, Yaping
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Poly (beta-amine esters)
Bioreducible
Non-viral vector
RNA delivery
Nanoparticles
Poly(epsilon-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation
期刊论文
PHARMACEUTICAL RESEARCH, 2010, 卷号: 27, 期号: 12, 页码: 2657-2669
作者:
Zhang, Pengcheng
;
Hu, Luojuan
;
Wang, Yucai
;
Wang, Jun
;
Feng, Linyin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
biodistribution
blood-brain barrier (BBB)
micelle
polyphosphoester
Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 卷号: 387, 期号: 1-2, 页码: 263-271
作者:
Gao, Yu
;
Xu, Pengfei
;
Chen, Lingli
;
Li, Yaping
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Prostaglandin E-1
Nanoparticles
Anti-inflammation
Allergenicity
Irritation
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