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科研机构
上海药物研究所 [412]
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期刊论文 [406]
会议论文 [4]
学位论文 [2]
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2021 [16]
2020 [13]
2019 [22]
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2016 [27]
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Pharmacol... [21]
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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 11, 页码: 2444-2452
作者:
Wang, Jiang
;
Yang, Dehua
;
Cheng, Xi
;
Yang, Linlin
;
Wang, Zhaohui
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
GADD45 beta stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 173, 页码: 11
作者:
Dong, Yunxia
;
Ma, Ningning
;
Fan, Lei
;
Yuan, Luyang
;
Wu, Qian
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/12/16
Non-alcoholic fatty liver disease
GADD45 beta
HSP72
Lipid accumulation
Insulin resistance
Transfersomes improved delivery of ascorbic palmitate into the viable epidermis for enhanced treatment of melasma
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 608, 页码: 10
作者:
Li, Junjun
;
Duan, Nianxiu
;
Song, Sha
;
Nie, Di
;
Yu, Miaorong
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Transfersome
Drug delivery
Ascorbic palmitate
Viable epidermis
Melasma treatment
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/01
Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2021, 卷号: 12, 页码: 14
作者:
Yang, Xinyu
;
Zhang, Xianfeng
;
Yang, Wei
;
Yu, Hang
;
He, Qianyan
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
gut microbiota
adipose tissue dysfunction
molecular endocrinology
cardiovascular disease(s)
gut dysbiosis
Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199
作者:
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Liang, Xiaoying
;
Lan, Yuan
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 页码: 6
作者:
Fan, Min
;
Wang, Ting
;
Peng, Li-Yan
;
Huang, Jun-Shang
;
Wu, Xing-De
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/11/04
Salvia hispanica
neo-clerodane diterpenoid
salvihispin H
type 2 diabetes mellitus
Honokiol: A naturally occurring lignan with pleiotropic bioactivities
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 卷号: 19, 期号: 7, 页码: 481-490
作者:
Chen Cheng
;
Zhang Qing-Wen
;
Ye Yang
;
Lin Li-Gen
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
Honokiol
Natural sources
Ethnopharmacological uses
Physicochemical properties
Bioactivities
Clinical trials
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