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The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia 期刊论文
PLOS ONE, 2016, 卷号: 11, 期号: 2, 页码: e0149043
作者:  Tan, Yong;  Liu, Xinru;  Zhou, Ke;  He, Xiaojuan;  Lu, Cheng
收藏  |  浏览/下载:12/0  |  提交时间:2019/12/27
Central neuromechanisms underlying control of intragastric pressure through acupuncture at Zusanli (ST36) in rats: the upper cervical cord is the key link between the ascending and descending pathways 期刊论文
Neural Regeneration Research, 2016, 卷号: 11, 期号: 6, 页码: 971-976
作者:  Yong, Chun-yan;  Chen, Shu;  Chen, Heng;  Chu, Xiao;  Zhang, Chao
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/27
Metabolic profiling reveals therapeutic biomarkers of processed Aconitum Carmichaeli Debx in treating hydrocortisone induced Kidney-Yang deficiency syndrome rats 期刊论文
Journal of Ethnopharmacology, 2014, 卷号: 152, 期号: 3, 页码: 585-593
作者:  Tan, Yong;  Liu, Xinru;  Lu, Cheng;  He, Xiaojuan;  Li, Jian
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/27
TCM  traditional Chinese medicine  KYDS  Kidney-Yang Deficiency syndrome  HPLC  high-performance liquid chromatography  LC/MS  high-pressure liquid chromatography combined mass spectrometry  LC-Q-TOF-MS  liquid chromatography quadruple time-of-flight mass spectrometry  EIC  extracted ion chromatograms  ESI  electrospray ionization  PCA  principal components analysis  PLS-DA  partial-least-squares discriminate analysis  OPLS  orthogonal partial least square  IPA  ingenuity pathway analysis  cAMP  cyclic adenosine monophosphate  cGMP  cyclic guanosine monophosphate  ACTH  adrenocorticotrophic hormone  CHM  Chinese herbal medicines  Metabolic profiling  Processed Aconitum carmichaeli debx  Therapeutic biomarkers  Kidney-Yang deficiency syndrome rats  
MiRNA-15a mediates cell cycle arrest and potentiates apoptosis in breast cancer cells by targeting synuclein-gamma. 期刊论文
Asian Pacific journal of cancer prevention : APJCP, 2014, 卷号: 15, 期号: 16, 页码: 6949-6954
作者:  Li, Ping;  Xie, Xiao-Bing;  Chen, Qian;  Pang, Guo-Lian;  Luo, Wan
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/27
Metal-free synthesis of oxindoles via (NH4)2S2O8-mediated halocarbocyclization of alkenes in water 期刊论文
Journal of Organic Chemistry, 2014, 卷号: 79, 期号: 22, 页码: 10829-10836
作者:  Zhang, Ming-Zhong;  Sheng, Wen-Bing;  Jiang, Qing;  Tian, Mi;  Yin, Yong
收藏  |  浏览/下载:1/0  |  提交时间:2019/12/27
Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy 期刊论文
Bioorganic and Medicinal Chemistry Letters, 2013, 卷号: 23, 期号: 13, 页码: 3905-3909
作者:  Yang, Yang;  Yan, Yong-Ming;  Wei, Wei;  Luo, Jie;  Zhang, Lan-Sheng
收藏  |  浏览/下载:1/0  |  提交时间:2019/12/27
Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation 期刊论文
Journal of natural products, 2011, 卷号: 74, 期号: 6, 页码: 1521-1525
作者:  Li, Xue-Song;  Zhou, Xiao-Jiang;  Zhang, Xing-Jie;  Su, Jia;  Li, Xue-Jing
收藏  |  浏览/下载:1/0  |  提交时间:2019/12/27
Antioxidant phenolics from Broussonetia papyrifera fruits 期刊论文
Journal of Asian natural products research, 2010, 卷号: 12, 期号: 5, 页码: 399-406
作者:  Zhou, Xiao-Jiang;  Mei, Ren-Qiang;  Zhang, Li;  Lu, Qing;  Zhao, Jun
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/27


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