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科研机构
中南大学 [6]
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期刊论文 [6]
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2018 [1]
2017 [1]
2016 [3]
2015 [1]
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专题:中南大学
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A 10-Year Statistical Analysis of Heavy Metals in River and Sediment in Hengyang Segment, Xiangjiang River Basin, China
期刊论文
Sustainability, 2018, 卷号: 10, 期号: 4, 页码: 1057-
作者:
Tang, Jingwen
;
Chai, Liyuan
;
Li, Huan
;
Yang, Zhihui
;
Yang, Weichun*
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
heavy metals
river
sediment
statistics
Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China
期刊论文
Journal of Hematology & Oncology, 2017, 卷号: 10, 期号: 1, 页码: 69-
作者:
Shi, Yuankai*
;
Jia, Bo
;
Xu, Wei
;
Li, Wenyu
;
Liu, Ting
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/03
Chemotherapy
Chidamide
Peripheral T cell lymphoma
Treatment
Biosynthesis of schwertmannite by Acidithiobacillus ferrooxidans and its application in arsenic immobilization in the contaminated soil
期刊论文
Journal of Soils and Sediments, 2016, 卷号: 16, 期号: 10, 页码: 2430-2438
作者:
Chai, Liyuan
;
Tang, Jingwen
;
Liao, Yingping
;
Yang, Zhihui
;
Liang, Lifeng
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Arsenic-contaminated soil
Arsenic immobilization
Biogenetic schwertmannite
Mine area
Effect of pre-deformation on creep age forming of AA2219 plate: Springback, microstructures and mechanical properties
期刊论文
Journal of Materials Processing Technology, 2016, 卷号: 229, 页码: 697-702
作者:
Yang, Youliang
;
Zhan, Lihua*
;
Ma, Qiangqiang
;
Feng, Jingwen
;
Li, Xianmeng
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/12/03
2219 aluminum alloy
Creep age forming
Pre-deformation
Springback
Mechanical properties
Microstructures
Characterization of arsenic serious-contaminated soils from Shimen realgar mine area, the Asian largest realgar deposit in China
期刊论文
Journal of Soils and Sediments, 2016, 卷号: 16, 期号: 5, 页码: 1519-1528
作者:
Tang, Jingwen
;
Liao, Yingping
;
Yang, Zhihui
;
Chai, Liyuan
;
Yang, Weichun*
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Arsenic
NaHCO3-extractable As
Sequential extraction
Soil profile
Water-soluble As
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:
Zhang, Lei
;
Xu, Xuan
;
Yang, Ruhao
;
Chen, Jingwen
;
Wang, Shixuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However
the underlying molecular mechanism remains unclear. In this study
we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3
and inhibited the expression of fibronectin
alpha-smooth muscle actin (α-SMA)
and collagen I in cultured NRK-49F cells. S3I-201
an STAT3 inhibitor
also suppressed the expression of fibronectin
α-SMA
and collagen I in cultured NRK-49F cells. Mechanistically
paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore
paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin
α-SMA
and collagen I
and suppressed the infiltration of macrophages and production of TNF-α
IL-1β
TGF-β
and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation
consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis
and inhibition of proinflammatory cytokine production.
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