CORC

在结果中检索

CORC

浏览/检索结果: 共14条，第1-10条 帮助

限定条件                
已选(0)清除 条数/页：   排序方式：
microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 105, 页码: 1147-1154
作者:  Jiang, Xue-Mei;  Yu, Xiang-Nan;  Liu, Tao-Tao;  Zhu, Hai-Rong;  Shi, Xuan
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/03
A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel-based morphometry study 期刊论文
CNS Neuroscience & Therapeutics, 2018, 卷号: 24, 期号: 11, 页码: 1073-1083
作者:  Lu, Xiao-Wen;  Guo, Hua;  Sun, Jing-Rong;  Dong, Qiang-Li;  Zhao, Fu-Tao
收藏  |  浏览/下载：17/0  |  提交时间：2019/12/03
China experts consensus on the diagnosis and treatment of advanced stage primary lung cancer (2016 version) 期刊论文
Asia‐Pacific Journal of Clinical Oncology, 2017, 卷号: 13, 期号: 1, 页码: 87-103
作者:  Shi, Yuankai*;  Sun, Yan;  Yu, Jinming;  Ding, Cuimin;  Wang, Ziping
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery. 期刊论文
BJA British Journal of Anaesthesia, 2017, 卷号: 119, 期号: 2, 页码: 258-266
作者:  Ahmad, T.;  Bouwman, R. A.;  Grigoras, I.;  Aldecoa, C.;  Hofer, C.
收藏  |  浏览/下载：119/0  |  提交时间：2019/12/03
Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129 期刊论文
Molecular Neurodegeneration, 2017, 卷号: 12, 期号: 1, 页码: 38
作者:  Zeng, Wen-Bo;  Jiang, Hai-Fei;  Gang, Ya-Dong;  Song, Yi-Ge;  Shen, Zhang-Zhou
收藏  |  浏览/下载：46/0  |  提交时间：2019/12/03
p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 43409
作者:  Yang, Ruhao;  Xu, Xuan;  Li, Huiling;  Chen, Jinwen;  Xiang, Xudong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Association Between Tibial Plateau Slopes and Anterior Cruciate Ligament Injury: A Meta-analysis 期刊论文
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2017, 卷号: 33, 期号: 6, 页码: 1248-1259.e4
作者:  Wang, Yi-Lun;  Yang, Tuo;  Zeng, Chao;  Wei, Jie;  Xie, Dong-Xing
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/03
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries The International Surgical Outcomes Study group 期刊论文
British Journal of Anaesthesia, 2016, 卷号: 117, 期号: 5, 页码: 601-609
作者:  Ahmad, T.;  Bouwman, R. A.;  Grigoras, I.;  Aldecoa, C.;  Hofer, C.
收藏  |  浏览/下载：78/0  |  提交时间：2019/12/03
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23 期刊论文
Nature Genetics, 2013, 卷号: 45, 期号: 11, 页码: 1361-1365
作者:  Li, Yongzhe;  Zhang, Kunlin;  Chen, Hua;  Sun, Fei;  Xu, Juanjuan
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/03

©版权所有 ©2017 CSpace - Powered by CSpace