CORC

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CORC

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Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma 期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:  Chen, Zi-qi;  Cao, Zhe-rui;  Wang, Yi;  Zhang, Xi;  Xu, Lan
收藏  |  浏览/下载：53/0  |  提交时间：2021/12/16
CYH33  MYC  P300  BET  B cell lymphoma  PI3K  
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1 期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:  Zhang, Chun;  Sun, Yi-Tao;  Gao, Li-Xin;  Feng, Bo;  Yan, Xue
收藏  |  浏览/下载：21/0  |  提交时间：2022/01/18
Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13
作者:  Wang, Yu-xiang;  Zhang, Xu;  Ma, Qing-yang;  Hu, Lan-dian;  Zhang, Xi
收藏  |  浏览/下载：47/0  |  提交时间：2021/05/24
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24
Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:  Zheng, Yuan-dong;  Zhang, Hua;  Zhan, Yan;  Bian, Yi-cong;  Ma, Sheng
收藏  |  浏览/下载：44/0  |  提交时间：2021/05/24
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01
Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3K alpha inhibition in breast cancer 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2019, 卷号: 4, 页码: 3
作者:  Liu, Xue-Ling;  Wang, Bo-Bo;  Wang, Yi;  Wang, Yu-Xiang;  Yang, Chun-hao
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01
Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3274-3281
作者:  Zang, Yi;  Gong, Yi-Hua;  Li, Xu-Wen;  Li, Xiao-Nian;  Liu, Jun-Jun
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/01
Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 83, 期号: 6, 页码: 3348-3353
作者:  Yang, Yuanyong;  Li, Yingxian;  Cheng, Cheng;  Yang, Guo
收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08
Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K alpha-selective inhibitor CYH33 in breast cancer 期刊论文
CANCER LETTERS, 2018, 卷号: 433, 页码: 273-282
作者:  Liu, Xue-ling;  Xu, Yi-chao;  Wang, Yu-xiang;  Chen, Yi;  Wang, Bo-bo
收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08

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