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科研机构
上海药物研究所 [379]
内容类型
期刊论文 [376]
会议论文 [3]
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2021 [36]
2020 [26]
2019 [20]
2018 [30]
2017 [27]
2016 [44]
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Pharmacolo... [9]
Chemistry [7]
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Rapid nucleic acid detection of Escherichia coli O157:H7 based on CRISPR/ Cas12a system
期刊论文
FOOD CONTROL, 2021, 卷号: 130, 页码: 8
作者:
Wang, Shujuan
;
Fan, Yiling
;
Feng, Zhen
;
Song, Minghui
;
Li, Qiongqiong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
CRISPR/Cas12a
Fe3O4@PDA@UiO-66-NH2
Nucleic acid
Detection Escherichia coli O157:H7
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Chen, Cheng
;
Ren, Yong-mei
;
Zhu, Jian-zhong
;
Chen, Jia-li
;
Feng, Zhe-ling
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/01/04
Ainsliadimer C
interleukin-1 beta
macrophages
NLRP3 inflammasome
Sirtuin 1
adipose tissue inflammation
obesity
metabolic disorders
EX-527
dexamethasone
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088
作者:
Lu, Tian
;
Lu, Haibo
;
Duan, Zhe
;
Wang, Jun
;
Han, Jie
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 13
作者:
Zhang, Huibing
;
Chen, Li-Nan
;
Yang, Dehua
;
Mao, Chunyou
;
Shen, Qingya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 14
作者:
Feng, Mei
;
Wu, Zhongen
;
Zhou, Yan
;
Wei, Zhuang
;
Tian, Enming
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2021, 页码: 14
作者:
Duan, Nianxiu
;
Li, Junjun
;
Song, Sha
;
Wang, Feng
;
Yang, Yiwei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/11/04
drug delivery
pancreatic cancer
prodrugs
smart liposomes
tumor-specific vascular promotion
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11
作者:
Qi, Qing
;
Li, Qian
;
Zhu, Hongwen
;
Lu, Huimin
;
Yang, Xiaoqian
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/08/17
Triptolide
LLDT-8
Psoriasis
IL-36 alpha
IL-36 alpha pathway
Inflammation
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