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科研机构
上海药物研究所 [16]
内容类型
期刊论文 [16]
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2021 [1]
2020 [3]
2018 [1]
2017 [2]
2016 [1]
2015 [2]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:
Wang, Zheng
;
Li, Zeng-xia
;
Zhao, Wen-cao
;
Huang, Hong-bo
;
Wang, Jia-qi
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/12/24
grincamycin B
marine natural product
isocitrate dehydrogenase 1
apoptosis
ER stress
intracellular ROS
Zebrafish embryos
hematological malignancies
An integrated strategy for holistic quality identification of Chinese patent medicine:Liuwei Dihuang Pillsas a case study
期刊论文
PHYTOCHEMICAL ANALYSIS, 2020, 页码: 15
作者:
Wang, Xia
;
Wu, Wenyong
;
Zhang, Jianqing
;
Gao, Lei
;
Zhang, Linlin
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  |  
浏览/下载:65/0
  |  
提交时间:2020/12/24
characteristic compound
holistic identification
LC-MS
LWDHP
multivariate statistical analysis
A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 348-357
作者:
Yan, Xiao-xia
;
Li, Hai-long
;
Zhang, Yi-ting
;
Wu, Shou-yan
;
Lu, Heng-lei
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
manganese superoxide dismutase
5-fluorouracil
chemotherapy
intestinal mucositis
diarrhea
oxidative stress
cytokines
intestinal microbes
The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168
期刊论文
NATURE CELL BIOLOGY, 2018, 卷号: 20, 期号: 3, 页码: 320-+
作者:
Xie, Xiaoduo
;
Hu, Hongli
;
Tong, Xinyuan
;
Li, Long
;
Liu, Xiangyuan
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse nonalcoholic steatohepatitis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 5, 页码: 660-671
作者:
Liu, Ming-xia
;
Gao, Man
;
Li, Chun-zhu
;
Yu, Cun-zhi
;
Yan, Hong
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
non-alcoholic steatohepatitis
cholesterol accumulation
Dicer1
HMGCR
microRNA-29
MCD diet-treated mice
MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 110-119
作者:
Li, Cheng-gang
;
Pu, Meng-fan
;
Li, Chun-zhu
;
Gao, Man
;
Liu, Ming-xia
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
miR-1304
NSCLC
heme oxygenase-1
hemin
NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 7, 页码: 984-993
作者:
Yu, Jun-lan
;
Chen, Tian-tian
;
Zhou, Chen
;
Lian, Fu-lin
;
Tang, Xu-long
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
fragment-based lead discovery
NMR
bromodomain
BRD4 inhibitors
Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 86, 期号: 5, 页码: 1161-1167
作者:
Wang, Wen-Long
;
Chen, Xia
;
Gao, Li-Xin
;
Sheng, Li
;
Li, Jing-Ya
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives
inhibitors
one-pot synthesis
protein tyrosine phosphatase 1B
structure-activity relationships
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 3, 页码: 708-716
作者:
An, Xiao-De
;
Liu, Hongyan
;
Xu, Zhong-Liang
;
Jin, Yi
;
Peng, Xia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
c-Met tyrosine kinase
Small molecule inhibitor
Imidazonaphthyridinone
Imidazopyridine
Binding mode
Pyridone-3-carboxamide
Cyclopropane-1,1-dicarboxamide
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