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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2021 [2]
2017 [3]
2016 [1]
2014 [1]
2013 [2]
2012 [1]
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Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Chen, Cheng
;
Ren, Yong-mei
;
Zhu, Jian-zhong
;
Chen, Jia-li
;
Feng, Zhe-ling
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/01/04
Ainsliadimer C
interleukin-1 beta
macrophages
NLRP3 inflammasome
Sirtuin 1
adipose tissue inflammation
obesity
metabolic disorders
EX-527
dexamethasone
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse nonalcoholic steatohepatitis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 5, 页码: 660-671
作者:
Liu, Ming-xia
;
Gao, Man
;
Li, Chun-zhu
;
Yu, Cun-zhi
;
Yan, Hong
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
non-alcoholic steatohepatitis
cholesterol accumulation
Dicer1
HMGCR
microRNA-29
MCD diet-treated mice
1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G(2)/M phase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4, 页码: 561-570
作者:
Peng, Chun
;
Qi, Xin-ming
;
Miao, Ling-ling
;
Ren, Jin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
1,2:5,6-dianhydrogalactitol
human glioblastoma
cell cycle arrest
p53-p21 cascade
CDC25C-CDK1 cascade
radiosensitivity
xenografted tumors
MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 110-119
作者:
Li, Cheng-gang
;
Pu, Meng-fan
;
Li, Chun-zhu
;
Gao, Man
;
Liu, Ming-xia
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
miR-1304
NSCLC
heme oxygenase-1
hemin
Identification and Structural Characterization of Acylgluconic Acids, Flavonol Glycosides, Limonoids and Alkaloids from the Fruits of Evodia Rutaecarpa by High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2016, 卷号: 54, 期号: 9, 页码: 1593-1604
作者:
Ling, Yun
;
Hu, Pei
;
Zhang, Lifang
;
Jin, Hongguang
;
Chen, Jian
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 83, 页码: 15-25
作者:
Liao, Ben-Ren
;
He, Hai-Bing
;
Yang, Ling-Ling
;
Gao, Li-Xin
;
Chang, Liang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Diabetes
Antidiabetic
Fructose-1,6-bisphosphatase (FBPase)
Inhibitor
2,5-Diphenyl-1,3,4-oxadiazoles
CoMFA, CoMSIA and HQSAR Studies of Acetylcholinesterase Inhibitors
期刊论文
CURRENT COMPUTER-AIDED DRUG DESIGN, 2013, 卷号: 9, 期号: 3, 页码: 385-395
作者:
Jiang, Yu-Ren
;
Yang, Yan-Yan
;
Chen, Yu-Ling
;
Liang, Zhong-Jie
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
AChE inhibitors
atom-fit alignment
CoMFA
CoMSIA
database alignment
HQSAR
multi-fit alignment
QSAR
ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9, 页码: 1229-1236
作者:
Qi, Xin-ming
;
Miao, Ling-ling
;
Cai, Yan
;
Gong, Li-kun
;
Ren, Jin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
tetrandrine
mitochondria
reactive oxygen species
cytochrome P450
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 24, 页码: 7440-7443
作者:
Dai, Hou-ling
;
Gao, Li-xin
;
Yang, Ying
;
Li, Jing-ya
;
Cheng, Jia-gao
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Molecular docking
Inhibitors
Di-indolinone
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