QQ客服 官方微博 反馈留言

浏览/检索结果: 共5条，第1-5条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity 期刊论文 PLOS ONE, 2012, 卷号: 7, 期号: 6 作者:  Kumar, Anuradha;  Zhang, Meng;  Zhu, Linyun;  Liao, Reiling P.;  Mutai, Charles 收藏  |  浏览/下载：10/0  |  提交时间：2019/01/08 Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide 期刊论文 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 卷号: 458, 期号: 2, 页码: 167-174 作者:  Sun, Ling;  Chen, Chong S.;  Waxman, David J.;  Liu, Hong;  Halpert, James R. 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 cytochrome p450  P4502B11  P450 engineering  structure-function relationships  site-directed mutagenesis  enzyme catalysis   Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis 期刊论文 DRUG METABOLISM AND DISPOSITION, 2006, 卷号: 34, 期号: 12, 页码: 1958-1965 作者:  Kumar, Santosh;  Liu, Hong;  Halpert, James R. 收藏  |  浏览/下载：12/0  |  提交时间：2019/01/08 Engineering mammalian cytochrome P4502B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide 期刊论文 PROTEIN ENGINEERING DESIGN & SELECTION, 2006, 卷号: 19, 期号: 12, 页码: 547-554 作者:  Kumar, Santosh;  Sun, Ling;  Liu, Hong;  Muralidhara, B. K.;  Halpert, James R. 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 cytochrome P450  directed evolution  heme accessibility  random mutagenesis  thermostability   Investigation of the role of cytochrome P4502B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme 期刊论文 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 卷号: 455, 期号: 1, 页码: 61-67 作者:  Hernandez, Cynthia E.;  Kumar, Santosh;  Liu, Hong;  Halpert, James R. 收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 cytochrome P450  structure function relationships  site-directed mutagenesis  enzyme catalysis and inhibition  P450 2134 crystal structure