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科研机构
山东大学 [18]
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期刊论文 [18]
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2019 [2]
2018 [3]
2017 [2]
2016 [3]
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2013 [1]
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专题:山东大学
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Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 73-86
作者:
Zhao, Wei
;
He, Long
;
Xiang, Tian-Le
;
Tang, Ya-Jie
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Tubulin
Colchicine domain
Podophyllotoxin
Binding affinity
Nanomolar-potency antitumor activity
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
European Journal of Medicinal Chemistry, 2019, 页码: 73-86
作者:
Zhao W.
;
He L.
;
Xiang T.-L.
;
Tang Y.-J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Binding affinity
Colchicine domain
Nanomolar-potency antitumor activity
Podophyllotoxin
Tubulin
Molecular modeling and chemometric analysis of osteoporosis calmodulin-TRPV1 binding affinity by statistically characterizing complex interactions
期刊论文
JOURNAL OF CHEMOMETRICS, 2018, 卷号: 32, 期号: 5
作者:
Liu, Xudong
;
Zhu, Limin
;
Wang, Lei
;
Yu, Lingzhi
;
Gao, Cong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
calmodulin
chemometric analysis
molecular modeling
osteoporosis
transient receptor potential vanilloid 1
Enhancement in catalytic activity of Aspergillus niger XynB by selective site-directed mutagenesis of active site amino acids
期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2018, 卷号: 102, 期号: 1, 页码: 249-260
作者:
Wu, Xiuyun
;
Tian, Zhennan
;
Jiang, Xukai
;
Zhang, Qun
;
Wang, Lushan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
GH11xylanase
Active site architecture
Rational design
Binding
affinity
Catalytic activity
Rs4705342 polymorphism is involved in the tumorigenesis of HBV positive HCC by altering the binding affinity of HBV induced NF-kB with the promoter region of microRNA-143
期刊论文
JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 卷号: 119, 期号: 7, 页码: 5233-5242
作者:
Yin, Xiuli
;
Sun, Shiying
;
Zhao, Junyan
;
Yang, Jing
;
Lei, Xiaofei
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
HBV
HBX
HCC
microRNA-143
NF-kB
ORP8
Rs4705342
tumorigenesis
Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2017, 卷号: 35, 期号: 9, 页码: 1849-1862
作者:
Kong, Yi
;
Wang, Zhen
;
Jia, Yanfei
;
Li, Ping
;
Hao, Shuhua
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/12
DNA-binding affinity
DEC1/2
protein comparative modeling
molecular
dynamics simulation
Thermal responsiveness and binding affinity of cucurbit[7]uril terminal poly(N-isopropylacrylamide)
期刊论文
NEW JOURNAL OF CHEMISTRY, 2017, 卷号: 41, 期号: 24, 页码: 14831-14834
作者:
Hou, Shengzhen
;
Chen, Hao
;
Qiu, Xiumin
;
Xu, Wenchao
;
Tan, Yebang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/12
Quantitative Determination of Substrate Binding Affinity Influenced by a Single Amino Acid Mutation in Cellulase Active-site Architecture Using Fluorescent Spectrometry
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2016, 卷号: 43, 期号: 11, 页码: 1086-1093
作者:
Wang Pei-Pei
;
Zhang Li-Li
;
Zhang Qing
;
Wang Lu-Shan
;
Chen Guan-Jun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/16
fluorescent spectrometry
cellulase
tryptophan
active-site
architecture
binding affinity
quantitative analysis
Interplay between binding affinity and kinetics in protein-protein interactions
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2016, 卷号: 84, 期号: 7, 页码: 920-933
作者:
Cao, Huaiqing
;
Huang, Yongqi
;
Liu, Zhirong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
intrinsically disordered proteins
protein-protein interaction
binding
affinity
coarse-grained model
linear free-energy relationship
Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 卷号: 1860, 期号: 4, 页码: 844-855
作者:
Xue, Jiajun
;
Jin, Lan
;
Zhang, Xinke
;
Wang, Fengshan
;
Ling, Peixue
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
Carbohydrate biosynthesis
Glycosaminoglycan
Chondroitin polymerase
Substrate specificity
Catalytic mechanism
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