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科研机构
上海药物研究所 [70]
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期刊论文 [70]
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2020 [3]
2017 [1]
2016 [6]
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Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 293-302
作者:
Wang, Jin-tao
;
Zheng, Yue-ming
;
Chen, Yue-ting
;
Gu, Min
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Nav1
7 sodium channel
aryl sulfonamide
maprotiline
compound 10o
electrophysiology
acetic acid-induced visceral pain
analgesic activity
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
discoveryofarylsulfonamideselectivenav17inhibitorswithahighlyhydrophobicethanoanthracenecore
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 293
作者:
Wang Jintao
;
Zheng Yueming
;
Chen Yueting
;
Gu Min
;
Gao Zhaobing
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Nav1.7 sodium channel
aryl sulfonamide
maprotiline
compound 10o
electrophysiology
acetic acid-induced visceral pain
analgesic activity
Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity
期刊论文
EBioMedicine, 2018, 卷号: 34, 页码: 201-213
作者:
Fan, Hui-Ran
;
Du, Wei-Feng
;
Zhu, Tao
;
Wu, Yan-Jiao
;
Liu, Yan-Mei
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
An allosteric ligand-binding site in the extracellular cap of K2P channels
期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8
作者:
Luo, Qichao
;
Chen, Liping
;
Cheng, Xi
;
Ma, Yuqin
;
Li, Xiaona
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 卷号: 791, 页码: 168-178
作者:
Han, Sheng-Na
;
Jing, Ying
;
Yang, Lin-Lin
;
Zhang, Zhao
;
Zhang, Li-Rong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Propofol
QT prolongation
Human ether-a-go-go-related gene (hERG)
Protein trafficking
Gene mutation
Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 2, 页码: 166-176
作者:
Zhang, Qi
;
Guo, Fei
;
Fu, Zhi-wen
;
Zhang, Bing
;
Huang, Cheng-gang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Rhizoma Anemarrhenae
timosaponin
YY-23
depression
NMDA receptor antagonist
chronic mild stress
chronic social defeat stress
fluoxetine
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Lead compound optimization strategy (5) - reducing the hERG cardiac toxicity in drug development
期刊论文
Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 10, 页码: 1530-1539
作者:
Zhou Shengbin
;
Wang Jiang
;
Liu Hong
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
hERG
lead compound optimization
lipophilicity
basicity
conformation restriction
cardiac toxicity
timosaponinderivativeyy23actsasanoncompetitivenmdareceptorantagonistandexertsarapidantidepressantlikeeffectinmice
期刊论文
actapharmacologicasinica, 2016, 卷号: 000, 期号: 002, 页码: 166
作者:
QiZHANG
;
Fei GUO
;
Zhi-wen FU
;
Bing ZHANG
;
Cheng-gang HUANG
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
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