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科研机构
上海药物研究所 [27]
内容类型
期刊论文 [27]
发表日期
2020 [1]
2019 [3]
2018 [2]
2017 [2]
2016 [5]
2015 [3]
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Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
new dinorditerpenoids from Flueggea virosa
期刊论文
FITOTERAPIA, 2019, 卷号: 133, 页码: 96-101
作者:
Wang, Xiao-Feng
;
Liu, Fei-Fei
;
Zhu, Zhengdan
;
Fang, Qiang-Qiang
;
Qu, Shi-Jin
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/04/02
Flueggea Virosa
13-methyl-ent-podocarpane
Securinega Alkaloids
Tddft Ecd
Anti-hcv
Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 5, 页码: 748-759
作者:
Guo, Shuang
;
Xu, Mingshuo
;
Guo, Qi
;
Zhu, Fuqiang
;
Jiang, Xiangrui
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Nucleoside
Double prodrug
Phosphoramidate
Anti-HCV
Pyrazine
Flueggenoids A - E, new dinorditerpenoids from Flueggea virosa
期刊论文
FITOTERAPIA, 2019, 卷号: 133, 页码: 96-101
作者:
Wang, Xiao-Feng
;
Liu, Fei-Fei
;
Zhu, Zhengdan
;
Fang, Qiang-Qiang
;
Qu, Shi-Jin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Flueggea virosa
13-Methyl-ent-podocarpane
Securinega alkaloids
TDDFT ECD
Anti-HCV
Caffeic acid inhibits HCV replication via induction of IFN alpha antiviral response through p62-mediated Keap1/Nrf2 signaling pathway
期刊论文
ANTIVIRAL RESEARCH, 2018, 卷号: 154, 页码: 166-173
作者:
Shen, Jian
;
Wang, Guifeng
;
Zuo, Jianping
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Caffeic acid
Keap1
Nrf2
HO-1
Facile synthesis of 2-C-methyl-D-arabino-gamma-1,4-lactones and mechanism study
期刊论文
TETRAHEDRON LETTERS, 2018, 卷号: 59, 期号: 15, 页码: 1473-1475
作者:
Lv, Bingqing
;
Guo, Shuang
;
Zhu, Fuqiang
;
Hu, Tianwen
;
Guo, Qi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Nucleoside
2-C-Methyl-D-arabino-gamma-lactone
Mechanism
SN2 reaction
O-18-labelled DMSO
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 133, 页码: 85-96
作者:
Tang, Jing
;
Vernekar, Sanjeev Kumar V.
;
Chen, Yue-Lei
;
Miller, Lena
;
Huber, Andrew D.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
2-hydroxyisoquinoline-1,3-diones
HIV
RNase H
Reverse transcriptase
Inhibitor
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:
Wang, Shuni
;
Wang, Yibing
;
Wang, Jiang
;
Sato, Tatsunori
;
Izawa, Kunisuke
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Hepatitis C virus (HCV)
pandemic
direct-acting antiviral agents (DAAs)
NS3/4A protease inhibitor
tailor-made amino acids
structure-activity relationship (SAR)
asymmetric synthesis
ring-closing metathesis (RCM)
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
Tailor-Made alpha-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)
期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 期号: 16, 页码: 2757-2774
作者:
Sato, Tatsunori
;
Izawa, Kunisuke
;
Luis Acena, Jose
;
Liu, Hong
;
Soloshonok, Vadim A.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Amino acids
Medicinal chemistry
Drug design
Antiviral agents
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