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Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET. 期刊论文
International Journal of Cancer, 2019, 卷号: 144, 期号: 3, 页码: 651-664
作者:  Shen, Yingying;  Zhang, Wei;  Liu, Jianghua;  He, Jun;  Cao, Renxian
收藏  |  浏览/下载:11/0  |  提交时间:2019/12/27
*AXL  *DCC-2036  *MET  *PDX  *TNBC  
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis 期刊论文
Clinica Chimica Acta, 2016, 卷号: 456, 页码: 81-88
作者:  Huang, Shifang;  Chen, Linxi;  Lu, Liqun;  Li, Lanfang*
收藏  |  浏览/下载:7/0  |  提交时间:2019/12/27
AT-1  angiotensin II type 1 receptor  VSMC  vascular smooth muscle cell  TGF-β1  transforming growth factor-β1  Ang-II  angiotensin II  ECM  extracellular matrix  CKD  chronic kidney disease  eNOS  endothelial nitric oxide synthase  UUO  unilateral ureteral obstruction  EMT  epithelial–mesenchymal transition  CAD  coronary artery disease  PAI-1  plasminogen activator inhibitor-1  SphK1  sphingosine kinase1  Post-MI  post-myocardial infarction  BMCs  bone marrow cells  HSCs  hepatic stellate cells  BA  biliary atresia  AII  angiotensin II  ET-1  endothelin-1  PDGFRβ  platelet-derived growth factor receptor β  ALC  alcoholic liver cirrhosis  HCV  hepatitis C virus  BA  biliary atresia  BPD  bronchopulmonary dysplasia  ARDS  acute respiratory distress syndrome  OA  oleic acid  PH  pulmonary hypertension  KLF2  Kruppel-like factor 2  Apelin–APJ  Renal fibrosis  Cardiac fibrosis  Liver fibrosis  Pulmonary fibrosis  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载:17/0  |  提交时间:2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载:19/0  |  提交时间:2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
MMPs and ADAMTSs in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 448, 页码: 238-246
作者:  Wang, Wen-Jun*;  Yu, Xiao-Hua;  Wang, Cheng;  Yang, Wei;  He, Wen-Si
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/27
IVD  intervertebral disc  IDD  intervertebral disc degeneration  ECM  extracellular matrix  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  NP  nucleus pulposus  AF  annulus fibrosus  Col I  type I collagen  Col II  type II collagen  IL-1  interleukin-1  MAPK  mitogen-activated protein kinase  MRI  magnetic resonance imaging  TIMP  tissue inhibitor of metalloproteinase  NGF  nerve growth factor  BMP  bone morphogenetic protein  TGF-β1  transforming growth factor-β1  SNPs  single nucleotide polymorphisms, miRNAs, microRNAs  LPS  lipopolysaccharide  TNF-α  tumor necrosis factor-α  NF-κB  nuclear factor κB  NO  nitric oxide  SDC4  syndecan-4  RSV  resveratrol  LfcinB  bovine lactoferricin  HO-1  heme oxygenase-1  MSCs  mesenchymal stem cells  IDD  MMPs  ADAMTSs  Col II  Aggrecan  
Efficacy and safety of angiogenesis inhibitors in advanced non-small cell lung cancer: a systematic review and meta-analysis 期刊论文
Journal of Cancer Research and Clinical Oncology, 2015, 卷号: 141, 期号: 5, 页码: 909-921
作者:  Hong, Shaodong;  Tan, Min;  Wang, Shouzheng;  Luo, Shengyuan;  Chen, Yue
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/27
MicroRNAs: New players in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 333-341
作者:  Wang, Cheng;  Wang, Wen-Jun;  Yan, Yi-Guo;  Xiang, Yong-Xiao;  Zhang, Jian
收藏  |  浏览/下载:22/0  |  提交时间:2019/12/27
IVD  intervertebral disc  NP  nucleus pulposus  AF  annulus fibrosus  CEPs  cartilaginous endplates  IDD  intervertebral disc degeneration  ECM  extracellular matrix  miRNAs  microRNAs  RNA pol  RNA polymerase  DGCR8  DiGeorge syndrome critical gene 8  Exp 5  exportin 5  TRBP  transactivating response RNA-binding protein  RISC  RNA-induced silencing complex  Ago  Argonaute  PI3K  phosphoinositide 3-kinase  MAPK  mitogen-activated protein kinase  TGF-β  transforming growth factor-β  PDGF  platelet-derived growth factor  IGF  insulin-like growth factor  EGF  epidermal growth factor  CDKI1B  cyclin-dependent kinase inhibitor 1B  TNF-α  tumor necrosis factor-α  FADD  Fas-associated death domain-containing protein  Col II  type II collagen  Col I  type I collagen  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  Col I  type I collagen  Col II  type II collagen  FGF2  fibroblast growth factor 2  FGFR  fibroblast growth factor receptor  IL-1β  interleukin-1β  NGF  nerve growth factor  HOXD10  homeobox D10  MiRNAs  IDD  NP cells  Apoptosis  Cell proliferation  
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. 期刊论文
Journal of lipid research, 2009, 卷号: 50, 期号: 12, 页码: 2389-2397
作者:  Jin, Junfei;  Mullen, Thomas D.;  Hou, Qi;  Bielawski, Jacek;  Bielawska, Alicja
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/27
Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature 期刊论文
Human Mutation, 2007, 卷号: 28, 期号: 8, 页码: 760-770
作者:  Gu, Dongqing;  Scaringe, William A.;  Li, Kai;  Saldivar, Juan-Sebastian;  Hill, Kathleen A.
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/27


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