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浏览/检索结果: 共44条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness 期刊论文 Developmental cell, 2018 作者:  Wang, Xinbo;  Jin, Jiali;  Wan, Fangning;  Zhao, Linlin;  Chu, Hongshang 收藏  |  浏览/下载：181/0  |  提交时间：2019/01/08 Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 597-609 作者:  Chen, Danqi 收藏  |  浏览/下载：90/0  |  提交时间：2019/01/08 Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK) 期刊论文 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 44, 页码: 16994-17007 作者:  Gu, Xin;  Bridges, Michael D.;  Yan, Yan;  de Waal, Parker W.;  Zhou, X. Edward 收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08 AMP-activated kinase (AMPK)  biophysics  diabetes  metabolic regulation  cancer  ADaM site  DEER   Elucidation of lid open and orientation of lipase activated in interfacial activation by amphiphilic environment 期刊论文 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 119, 页码: 1211-1217 作者:  Cheng, Cheng;  Jiang, Tianyue;  Wu, Yulu;  Cui, Lupeng;  Qin, Song 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 Lipase  Amphiphilic media  Interfacial activation   Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Olaleye, Olajide E;  Niu, Wei;  Du, Fei-Fei;  Wang, Feng-Qing;  Xu, Fang 收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 Artificial intelligence in drug design 期刊论文 SCIENCE CHINA-LIFE SCIENCES, 2018, 卷号: 61, 期号: 10, 页码: 1191-1204 作者:  Zhong, Feisheng;  Xing, Jing;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 drug design  artificial intelligence  deep learning  QSAR  ADME/T   Inhibiting mechanism of small molecule toward the p53-MDM2 interaction: A molecular dynamic exploration 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 4, 页码: 1763-1777 作者:  Chen, Jianzhong;  Wang, Jinan;  Pang, Laixue;  Zhu, Weiliang 收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 hydrophobic contact scanning  MM-GBSA  p53-MDM2 interaction  principal component analysis  solvated interaction energy   Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system 期刊论文 Toxicology and applied pharmacology, 2018, 卷号: 355, 页码: 18-27 作者:  Huang, Zhenlin;  Sheng, Yuchen;  Chen, Minwei;  Hao, Zhanxia;  Hu, Feifei 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products 期刊论文 CELL CHEMICAL BIOLOGY, 2018, 卷号: 25, 期号: 8, 页码: 984-+ 作者:  Xu, Jun-Yu;  Xu, Ya;  Xu, Zhen;  Zhai, Lin-Hui;  Ye, Yang 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Current Strategies and Applications for Precision Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Wang, Chen;  Xu, Pan;  Zhang, Luyu;  Huang, Jing;  Zhu, Kongkai 收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08 precision medicine  precision drug design  computational modeling  deep learning  antibody-drug conjugates  ligand-targeted conjugates