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山东大学 [24]
复旦大学上海医学院 [12]
武汉大学 [10]
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期刊论文 [121]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Pu
;
Meng, Ling-hua
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/12/21
phosphoinositide 3-kinase (PI3K)
PI3K inhibitors
tumor microenvironment
immune cells
immunotherapy
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:
Guo, Chuanlong
;
Wang, Lijun
;
Zhao, Yue
;
Jiang, Bo
;
Luo, Jiao
收藏
  |  
浏览/下载:117/0
  |  
提交时间:2019/08/28
bromophenol
apoptosis
autophagy
phosphoinositide 3-kinase
protein kinase B
mechanistic target of rapamycin signaling
reactive oxygen species
Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 115-118
作者:
Zhao, Jun-Wen
;
Yang, Zhong-Duo
;
Zhou, Shuan-Yan
;
Yang, Li-Jun
;
Sun, Jian-Hui
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/11/15
Wortmannine
Talaromyces wortmannii
Endophytic fungus
Phosphoinositide 3-kinase inhibitors
Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 115-118
作者:
Zhao, Jun-Wen
;
Yang, Zhong-Duo
;
Zhou, Shuan-Yan
;
Yang, Li-Jun
;
Sun, Jian-Hui
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/03/01
Wortmannine
Talaromyces wortmannii
Endophytic fungus
Phosphoinositide 3-kinase inhibitors
Laminar shear stress alters endothelial KCa2.3 expression in H9c2 cells partially via regulating the PI3K/Akt/p300 axis
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 卷号: 43, 期号: 3
作者:
Li, Guojian
;
Yang, Qionghui
;
Yang, Yong
;
Yang, Guokai
;
Wan, Jia
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/04
atrial fibrillation
laminar shear stress
Ca2+-activated K+ channel 2
3,phosphoinositide 3-kinase-protein kinase B-histone acetyltransferase p300
SHIP1 inhibits cell growth, migration, and invasion in non-small cell lung cancer through the PI3K/AKT pathway
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 期号: 4
作者:
Fu, Qiaofen
;
Huang, Yuhui
;
Ge, Chunlei
;
Li, Zhen
;
Tian, Hui
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/04
Src homology 2-containing inositol-5 '-phosphatase 1
non-small cell lung cancer
phosphoinositide 3-kinase/AKT
epithelial-mesenchymal transition
Targeting the BDNF/TrkB pathway for the treatment of tumors
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 17, 期号: 2
作者:
Ji, Rui
;
Meng, Lingbin
;
Liu, Baoqiong
;
Jiang, Xin
;
Yan, Xuebo
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
brain-derived neurotrophic factor
tropomyosin receptor kinase B
survival
apoptosis
anoikis
chemotherapy resistance
phosphoinositide 3-kinase
phospholipase-C-
mitogen-activated protein kinase
The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 期号: 5
作者:
Wang, Shengfei
;
Niu, Xiaomin
;
Bao, Xiao
;
Wang, Qin
;
Zhang, Jianping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
non-small cell lung cancer
bone metastasis
phosphoinositide-3-kinase inhibitor
multimodality molecular imaging
multiparametric quantification
miR-802 inhibits the aggressive behaviors of non-small cell lung cancer cells by directly targeting FGFR1
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2019, 卷号: 54, 期号: 6
作者:
Li, Jun
;
Zhang, Jiexia
;
Li, Shiyue
;
Zhou, Chengzhi
;
Qin, Yinyin
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/05
non-small cell lung cancer
miR-802
brain metastasis
fibroblast growth factor receptor 1
phosphoinositide 3-kinase
AKT serine
threonine kinase
mammalian target of rapamycin
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