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科研机构
南华大学 [19]
山东大学 [19]
复旦大学上海医学院 [19]
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期刊论文 [126]
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浏览/检索结果:
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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Minimally modified low-density lipoprotein upregulates the ETB and α1 receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
期刊论文
The Journal of pharmacy and pharmacology, 2019
作者:
Zeng Zhong-San
;
Lin Jie
;
Xu Cang-Bao
;
Cao Lei
;
Chen Chen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/11/19
PI3K/Akt pathway
ETB receptor
&alpha
1 receptor
minimally modified low-density lipoprotein
mice
mesenteric artery
LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel
期刊论文
International Journal of Cardiology, 2019, 卷号: Vol.275, 页码: 120-128
作者:
Dandan Liang
;
Yahan Wu
;
Liping Zhou
;
Yongli Chen
;
Hongyu Liu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/13
Low-density
lipoprotein
receptor-related
protein
QT
interval
Action
potential
duration
Myocyte
L-type
calcium
channel
Proteasomal
degradation
PCSK9 Inhibitors: Novel Therapeutic Strategies for Lowering LDL-Cholesterol
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 2, 页码: 165-176
作者:
Wang, Yan
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/11
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9)
low-density lipoprotein cholesterol (LDL-C)
low-density lipoprotein
receptor (LDLR)
cardiovascular disease (CVD)
hypercholesterolemia
alirocmab
evolocumab
Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
期刊论文
PHARMACEUTICAL BIOLOGY, 2019, 卷号: 57, 期号: 1, 页码: 98-104
作者:
Meng, Yuanyuan
;
Liu, Yong
;
Fang, Ningning
;
Guo, Yongmin
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
High-fat diet
antioxidant
low density lipoprotein receptor
TNF-alpha
IL-6
IL-8
Low-Density Lipoprotein Receptor-Related Protein 6 Is Essential for Trophoblast Survival and Invasion
期刊论文
REPRODUCTIVE SCIENCES, 2019, 卷号: 26, 期号: 1, 页码: 35-43
作者:
Li, Lei
;
Wan, Jipeng
;
Xue, Jing
;
Li, Hongyan
;
Wang, Shan
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
low-density lipoprotein
low-density lipoprotein receptor-related
protein 6
spiral artery remodeling
trophoblast
angiogenesis
LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel
期刊论文
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019, 卷号: Vol.275, 页码: 120-128
作者:
Liang, Dandan
;
Wu, Yahan
;
Zhou, Liping
;
Chen, Yongli
;
Liu, Hongyu
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/17
Low-density
lipoprotein
receptor-related
protein
QT
interval
Action
potential
duration
Myocyte
L-type
calcium
channel
Proteasomal
degradation
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
Minimally modified low-density lipoprotein upregulates the ETB and alpha1 receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
期刊论文
The Journal of pharmacy and pharmacology, 2019, 卷号: 71, 期号: 6, 页码: 937-944
作者:
Zeng, Zhong-San
;
Lin, Jie
;
Xu, Cang-Bao
;
Cao, Lei
;
Chen, Chen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/27
ETB receptor
PI3K/Akt pathway
mesenteric artery
mice
minimally modified low-density lipoprotein
alpha1 receptor
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
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